trans-7-(4-acetoxycyclohexyl)heptanoic acid

Base Information

• Chemical Name: trans-7-(4-acetoxycyclohexyl)heptanoic acid
• CAS No.: 107228-90-0
• Molecular Formula: C₁₅H₂₆O₄
• Molecular Weight: 270.369
• Mol file: 107228-90-0.mol

Synonyms:

Chemical Property of trans-7-(4-acetoxycyclohexyl)heptanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-7-(4-acetoxycyclohexyl)heptanoic acid

There total 3 articles about trans-7-(4-acetoxycyclohexyl)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-(4-methoxy-phenyl)-7-oxo-heptanoic acid (21244-11-1) → trans-7-(4-acetoxycyclohexyl)heptanoic acid (107228-90-0)

Guidance literature:

Multi-step reaction with 4 steps

1: Clemmensen reduction

2: 48 percent HBr / acetic acid

3: 34 percent / hydrogen / 5 percent Ru-C / ethanol; H₂O / 1 h / 102 - 104 °C / 84583.4 Torr

4: p-TsOH / 1 h / 60 - 70 °C

With hydrogen bromide; hydrogen; toluene-4-sulfonic acid; Ru-carbon; In ethanol; water; acetic acid;

DOI:10.1248/cpb.36.178

Reference yield:

7-(4-hydroxyphenyl)heptanoic acid (107228-95-5) → trans-7-(4-acetoxycyclohexyl)heptanoic acid (107228-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 34 percent / hydrogen / 5 percent Ru-C / ethanol; H₂O / 1 h / 102 - 104 °C / 84583.4 Torr

2: p-TsOH / 1 h / 60 - 70 °C

With hydrogen; toluene-4-sulfonic acid; Ru-carbon; In ethanol; water;

DOI:10.1248/cpb.36.178

Reference yield:

acetic anhydride (108-24-7) + trans-7-(4-hydroxycyclohexyl)heptanoic acid (107228-92-2) → trans-7-(4-acetoxycyclohexyl)heptanoic acid (107228-90-0)

Guidance literature:

With toluene-4-sulfonic acid; at 60 - 70 ℃; for 1h;

DOI:10.1248/cpb.36.178

upstream raw materials:

acetic anhydride

trans-7-(4-hydroxycyclohexyl)heptanoic acid

7-(4-methoxy-phenyl)-7-oxo-heptanoic acid

7-(4-hydroxyphenyl)heptanoic acid

Downstream raw materials:

Acetic acid 4-{7-[7-(4-acetoxy-cyclohexyl)-heptanoylperoxy]-7-oxo-heptyl}-cyclohexyl ester

Acetic acid 4-[6-(4,5-dimethoxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl)-hexyl]-cyclohexyl ester

trans-6-<6-(4-hydroxycyclohexyl)hexyl>-2,3-dimethoxy-5-methyl-1,4-benzoquinone