Benzoxazole, 2-(2-methoxyphenyl)-5-methyl-

Base Information

• Chemical Name: Benzoxazole, 2-(2-methoxyphenyl)-5-methyl-
• CAS No.: 101097-11-4
• Molecular Formula: C15H13NO2
• Molecular Weight: 239.274
• Mol file: 101097-11-4.mol

Synonyms:

Chemical Property of Benzoxazole, 2-(2-methoxyphenyl)-5-methyl-

Chemical Property:

• PSA: 35.26000
• LogP: 3.81180

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Methoxyphenyl)-5-methylbenzo[d]oxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoxazole, 2-(2-methoxyphenyl)-5-methyl-

There total 8 articles about Benzoxazole, 2-(2-methoxyphenyl)-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ortho-anisaldehyde (135-02-4) + 3-amino-4-hydroxytoluene (95-84-1) → 2-(2-methoxyphenyl)-5-methylbenzo[d]oxazole (101097-11-4)

Guidance literature:

With potassium carbonate; 1-methyl-3-(n-butyl)imidazolium iodide; In o-xylene; para-xylene; m-xylene; at 120 ℃; for 10h; Green chemistry;

DOI:10.1055/s-0036-1591524

Reference yield: 85.0%

5-methyl-1,3-benzoxazole (10531-78-9) + 2-Chloroanisole (766-51-8) → 2-(2-methoxyphenyl)-5-methylbenzo[d]oxazole (101097-11-4)

Guidance literature:

With PdCl₂(C₃H₃N₂(CH₃))(C₃H₂N₂(C₆H₃(C₃H₇)2)2); lithium tert-butoxide; In toluene; at 130 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ol500531m

Reference yield: 73.0%

2-methoxybenzylamine (6850-57-3) + 3-amino-4-hydroxytoluene (95-84-1) → 2-(2-methoxyphenyl)-5-methylbenzo[d]oxazole (101097-11-4)

Guidance literature:

With oxygen; iron(II) bromide; In chlorobenzene; at 120 ℃; for 26h; Schlenk technique; Green chemistry;

DOI:10.1039/c4ra12490a

upstream raw materials:

2-(2-Methoxy-benzylidenamino)-4-methylphenol

ortho-anisaldehyde

3-amino-4-hydroxytoluene

5-methyl-1,3-benzoxazole

Refernces

• 1、 Gopalaiah, Kovuru,Chandrudu, Sankala Naga. "Iron(II) bromide-catalyzed oxidative coupling of benzylamines with ortho-substituted anilines: Synthesis of 1,3-benzazoles". . p. 5015 - 5023. Retrieved 2015.
• 2、 Hanson, McKenna G.,Olson, Noelle M.,Yi, Zubaoyi,Wilson, Grace,Kalyani, Dipannita. "Nickel-Catalyzed Coupling of Azoles with Aromatic Nitriles". supporting information. p. 4271 - 4274. Retrieved 2017/08/23.