(4S,5S)-4-Cyclohexylmethyl-5-[(S)-2-(3-dimethylamino-propoxycarbonylamino)-3-methyl-butyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(4S,5S)-4-Cyclohexylmethyl-5-[(S)-2-(3-dimethylamino-propoxycarbonylamino)-3-methyl-butyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
CAS No.:140676-16-0
Molecular Formula:C₂₈H₅₃N₃O₅
Molecular Weight:511.746
Hs Code.:

(4S,5S)-4-Cyclohexylmethyl-5-[(S)-2-(3-dimethylamino-propoxycarbonylamino)-3-methyl-butyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5S)-4-Cyclohexylmethyl-5-[(S)-2-(3-dimethylamino-propoxycarbonylamino)-3-methyl-butyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Chemical Property:

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Technology Process of (4S,5S)-4-Cyclohexylmethyl-5-[(S)-2-(3-dimethylamino-propoxycarbonylamino)-3-methyl-butyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

There total 1 articles about (4S,5S)-4-Cyclohexylmethyl-5-[(S)-2-(3-dimethylamino-propoxycarbonylamino)-3-methyl-butyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3179-63-3
3-Dimethylamino-1-propanol

: 129921-93-3
2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

: 140676-16-0
(4S,5S)-4-Cyclohexylmethyl-5-[(S)-2-(3-dimethylamino-propoxycarbonylamino)-3-methyl-butyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; Yield given. Multistep reaction; 1.) toluene, 70 deg C, 1.5 h, 2.) toluene, reflux, 72 h;
DOI:10.1021/jm00088a007

Reference yield:

: 140676-16-0
(4S,5S)-4-Cyclohexylmethyl-5-[(S)-2-(3-dimethylamino-propoxycarbonylamino)-3-methyl-butyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: {(1S,3S,4S)-4-[(S)-2-Amino-3-(1H-imidazol-4-yl)-propionylamino]-5-cyclohexyl-3-hydroxy-1-isopropyl-pentyl}-carbamic acid 3-dimethylamino-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: TFA / 1.) CH₂Cl₂, 0 deg C, 3.5 h, 2.a.) THF, H₂O, 0 deg C, 4 h, b.) THF, H₂O, RT, 12 h

2: 2.) HOAc / 1 a.) CH₂Cl₂, 0 deg C, 6 h, b.) RT, 14 h, 2.) THF, water, 50 deg C, 5 h

3: TFA / CH₂Cl₂ / 4 h / 0 °C

With acetic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00088a007

Reference yield:

: 140676-16-0
(4S,5S)-4-Cyclohexylmethyl-5-[(S)-2-(3-dimethylamino-propoxycarbonylamino)-3-methyl-butyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 140660-75-9
((1S,3S,4S)-4-{(S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoylamino}-5-cyclohexyl-3-hydroxy-1-isopropyl-pentyl)-carbamic acid 3-dimethylamino-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / 1.) CH₂Cl₂, 0 deg C, 3.5 h, 2.a.) THF, H₂O, 0 deg C, 4 h, b.) THF, H₂O, RT, 12 h

2: 1-hydroxybenzotriazole hydrate (HOBT), 4-methylmorpholine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) / dimethylformamide / 1.) -23 deg C, 4 h, 2.) RT, 18 h

With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00088a007