[(1R,6S,10R)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-amine

Base Information

• Chemical Name: [(1R,6S,10R)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-amine
• CAS No.: 75209-85-7
• Molecular Formula: C₁₈H₂₇NO
• Molecular Weight: 273.418

Synonyms:

Chemical Property of [(1R,6S,10R)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(1R,6S,10R)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-amine

There total 26 articles about [(1R,6S,10R)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxyphenyl bromide (2398-37-0) → [(1R,6S,10S)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-amine (75209-85-7,75209-87-9)

Guidance literature:

Multi-step reaction with 13 steps

1: 1.) Mg / 1.) THF, 2.) THF, room temp., 30 min, 50-55 deg C, 1 h

2: oxalic acid / toluene / 16 h / Heating

3: 1.) NaBH₄, BF₃*Et₂O, 2.) 10percent NaOH, 30percent H₂O₂ / 1.) THF, room temp., 15 h, 2.) THF, H₂O, room temp., 1 h

4: 33.6 percent / Na₂Cr₂O₇*2H₂O, conc. H₂SO₄ / diethyl ether; H₂O / 2 h / 5 - 13 °C

5: 75.8 percent / TiCl₄ / benzene / 1.) room temp., overnight, 2.) 75-80 deg C, 8 h

6: 78 percent / benzene / 20 h / Heating

7: 90.3 percent / NH₂OH*HCl, NaOAc / dimethylformamide / Ambient temperature

8: 81.9 percent / LiAlH₄ / tetrahydrofuran; dioxane / Heating

9: 73.3 percent / 5percent NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

10: 80.2 percent / pyridine / 4 h / Ambient temperature

11: 44.3 percent / NaI, Zn / 1,2-dimethoxy-ethane / 76 h / Heating

12: 97.7 percent / H₂ / 10percent Pd-C / ethanol / 7.5 h / 70 - 90 °C / 47808 Torr

13: LiAlH₄ / diethyl ether / 8 h / Heating

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium dichromate; sulfuric acid; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; hydrogen; dihydrogen peroxide; sodium acetate; oxalic acid; titanium tetrachloride; sodium hydrogencarbonate; magnesium; sodium iodide; zinc; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1248/cpb.28.1022

Reference yield:

3-methoxyphenyl bromide (2398-37-0) → [(1R,6S,10R)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-amine (75209-85-7,75209-87-9)

Guidance literature:

Multi-step reaction with 13 steps

1: 1.) Mg / 1.) THF, 2.) THF, room temp., 30 min, 50-55 deg C, 1 h

2: oxalic acid / toluene / 16 h / Heating

3: 1.) NaBH₄, BF₃*Et₂O, 2.) 10percent NaOH, 30percent H₂O₂ / 1.) THF, room temp., 15 h, 2.) THF, H₂O, room temp., 1 h

4: 33.6 percent / Na₂Cr₂O₇*2H₂O, conc. H₂SO₄ / diethyl ether; H₂O / 2 h / 5 - 13 °C

5: 75.8 percent / TiCl₄ / benzene / 1.) room temp., overnight, 2.) 75-80 deg C, 8 h

6: 78 percent / benzene / 20 h / Heating

7: 90.3 percent / NH₂OH*HCl, NaOAc / dimethylformamide / Ambient temperature

8: 81.9 percent / LiAlH₄ / tetrahydrofuran; dioxane / Heating

9: 73.3 percent / 5percent NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

10: 80.2 percent / pyridine / 4 h / Ambient temperature

11: 44.3 percent / NaI, Zn / 1,2-dimethoxy-ethane / 76 h / Heating

12: 97.7 percent / H₂ / 10percent Pd-C / ethanol / 7.5 h / 70 - 90 °C / 47808 Torr

13: LiAlH₄ / tetrahydrofuran / 18 h / Heating

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium dichromate; sulfuric acid; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; hydrogen; dihydrogen peroxide; sodium acetate; oxalic acid; titanium tetrachloride; sodium hydrogencarbonate; magnesium; sodium iodide; zinc; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1248/cpb.28.1022

Reference yield:

1-(m-methoxyphenyl)cycloheptanol (2082-28-2) → [(1R,6S,10S)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-amine (75209-85-7,75209-87-9)

Guidance literature:

Multi-step reaction with 12 steps

1: oxalic acid / toluene / 16 h / Heating

2: 1.) NaBH₄, BF₃*Et₂O, 2.) 10percent NaOH, 30percent H₂O₂ / 1.) THF, room temp., 15 h, 2.) THF, H₂O, room temp., 1 h

3: 33.6 percent / Na₂Cr₂O₇*2H₂O, conc. H₂SO₄ / diethyl ether; H₂O / 2 h / 5 - 13 °C

4: 75.8 percent / TiCl₄ / benzene / 1.) room temp., overnight, 2.) 75-80 deg C, 8 h

5: 78 percent / benzene / 20 h / Heating

6: 90.3 percent / NH₂OH*HCl, NaOAc / dimethylformamide / Ambient temperature

7: 81.9 percent / LiAlH₄ / tetrahydrofuran; dioxane / Heating

8: 73.3 percent / 5percent NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

9: 80.2 percent / pyridine / 4 h / Ambient temperature

10: 44.3 percent / NaI, Zn / 1,2-dimethoxy-ethane / 76 h / Heating

11: 97.7 percent / H₂ / 10percent Pd-C / ethanol / 7.5 h / 70 - 90 °C / 47808 Torr

12: LiAlH₄ / diethyl ether / 8 h / Heating

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium dichromate; sulfuric acid; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; hydrogen; dihydrogen peroxide; sodium acetate; oxalic acid; titanium tetrachloride; sodium hydrogencarbonate; sodium iodide; zinc; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1248/cpb.28.1022

upstream raw materials:

10-endo-ethoxycarbamoyl-1-(m-methoxyphenyl)bicyclo<4.3.1>decane

3-methoxyphenyl bromide

1-(m-methoxyphenyl)cycloheptanol

2-(m-methoxyphenyl)-cycloheptanone

Downstream raw materials:

[(1R,6S,10S)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-phenethyl-amine; hydrobromide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 75209-85-7 [(1R,6S,10R)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-amine

Send

Send

Metric Ton KG G Pound L ML

Send

Send