N-Benzyloxy-N-(4-{[(4,6-bis-{[4-(acetyl-benzyloxy-amino)-butoxymethyl]-methyl-amino}-[1,3,5]triazin-2-yl)-methyl-amino]-methoxy}-butyl)-acetamide

Base Information

• Chemical Name: N-Benzyloxy-N-(4-{[(4,6-bis-{[4-(acetyl-benzyloxy-amino)-butoxymethyl]-methyl-amino}-[1,3,5]triazin-2-yl)-methyl-amino]-methoxy}-butyl)-acetamide
• CAS No.: 177498-85-0
• Molecular Formula: C₄₈H₆₉N₉O₉
• Molecular Weight: 916.131
• Mol file: 177498-85-0.mol

Synonyms:

Chemical Property of N-Benzyloxy-N-(4-{[(4,6-bis-{[4-(acetyl-benzyloxy-amino)-butoxymethyl]-methyl-amino}-[1,3,5]triazin-2-yl)-methyl-amino]-methoxy}-butyl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Benzyloxy-N-(4-{[(4,6-bis-{[4-(acetyl-benzyloxy-amino)-butoxymethyl]-methyl-amino}-[1,3,5]triazin-2-yl)-methyl-amino]-methoxy}-butyl)-acetamide

There total 5 articles about N-Benzyloxy-N-(4-{[(4,6-bis-{[4-(acetyl-benzyloxy-amino)-butoxymethyl]-methyl-amino}-[1,3,5]triazin-2-yl)-methyl-amino]-methoxy}-butyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

(1,3,5-triazine-2,4,6-triyl)tris(methylazanediyl)trimethanol (64124-21-6) + N-Benzyloxy-N-(4-hydroxy-butyl)-acetamide (177498-89-4) → N-Benzyloxy-N-(4-{[(4,6-bis-{[4-(acetyl-benzyloxy-amino)-butoxymethyl]-methyl-amino}-[1,3,5]triazin-2-yl)-methyl-amino]-methoxy}-butyl)-acetamide (177498-85-0)

Guidance literature:

With 4 A molecular sieve; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1021/jo9600621

Reference yield:

N-<(2,2,2-trichloroethoxy)carbonyl>-O-benzylhydroxylamine (90195-00-9) → N-Benzyloxy-N-(4-{[(4,6-bis-{[4-(acetyl-benzyloxy-amino)-butoxymethyl]-methyl-amino}-[1,3,5]triazin-2-yl)-methyl-amino]-methoxy}-butyl)-acetamide (177498-85-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, room temperature, 45 min, 2.) DMF, room temperature, overnight

2: 93 percent / Zn, AcOH / tetrahydrofuran / 2 h / Ambient temperature

3: 92 percent / K₂CO₃ / methanol; H₂O / Ambient temperature

4: 40 percent / p-TsOH, 4A molecular sieves / dimethylformamide / 48 h / Ambient temperature

With 4 A molecular sieve; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; zinc; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jo9600621

Reference yield:

Acetic acid 4-(acetyl-benzyloxy-amino)-butyl ester (177498-84-9) → N-Benzyloxy-N-(4-{[(4,6-bis-{[4-(acetyl-benzyloxy-amino)-butoxymethyl]-methyl-amino}-[1,3,5]triazin-2-yl)-methyl-amino]-methoxy}-butyl)-acetamide (177498-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / K₂CO₃ / methanol; H₂O / Ambient temperature

2: 40 percent / p-TsOH, 4A molecular sieves / dimethylformamide / 48 h / Ambient temperature

With 4 A molecular sieve; potassium carbonate; toluene-4-sulfonic acid; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jo9600621

upstream raw materials:

(1,3,5-triazine-2,4,6-triyl)tris(methylazanediyl)trimethanol

N-Benzyloxy-N-(4-hydroxy-butyl)-acetamide

N-<(2,2,2-trichloroethoxy)carbonyl>-O-benzylhydroxylamine

Acetic acid 4-(acetyl-benzyloxy-amino)-butyl ester