90195-00-9

Upstream product

• 622-33-3 N-benzyloxyamine 
• 17341-93-4 2,2,2-Trichloroethyl chloroformate 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 

Downstream Products

• 94136-42-2 4--N-(benzyloxy)amino>-1-butyl bromide 
• 94136-46-6 3-<<(trichloroethoxy)carbonyl>(benzyloxy)amino>-1-pentyl bromide 
• 110271-85-7 methyl glycolylglycolate 
• 110271-84-6 O-Benzyl-N-methyl-N-<(2,2,2-trichloroethoxy)carbonyl>hydroxylamine 
• 110271-68-6 C₁₃H₁₄Cl₃NO₅ 
• 110271-75-5 5-Methoxy-4-methyl-[1,2,3]oxadiazole-2,3-dicarboxylic acid diisopropyl ester 
• 110271-69-7 C₁₄H₁₆Cl₃NO₅ 
• 110271-76-6 4-Ethyl-5-methoxy-[1,2,3]oxadiazole-2,3-dicarboxylic acid diisopropyl ester 
• 110271-70-0 C₁₅H₁₈Cl₃NO₅ 
• 110271-83-5 C₁₈H₂₄N₂O₆ 
• 110271-79-9 4-Benzyl-5-methoxy-[1,2,3]oxadiazole-2,3-dicarboxylic acid diisopropyl ester 
• 110271-73-3 C₂₀H₂₀Cl₃NO₅ 
• 124620-52-6 N²-(benzyloxycarbonyl)-N⁵-(benzyloxy)-N⁵-<(2,2,2-trichloroethoxy)carbonyl>-L-ornithine 1-tert-butyl ester 
• 153492-08-1 1-<(tert-Butoxycarbonyl)amino>-5-<(trichloroethoxycarbonyl)(benzyloxy)amino>pentane 

Relevant academic research and scientific papers

ANTIBACTERIAL SIDEROMYCINS

A compound, comprising: an Fe(III)-binding and/or Fe(III)-bound siderophore; one or more optional linker covalently bound to the siderophore; and daptomycin covalently bound to the linker, or, if no linker is present, then to the siderophore; or pharmaceu

2-thiosubstituted carbapenems

Carbapenem antibiotic compounds of the general formula: STR1 wherein the moiety STR2 is a 4, 5 or 6 membered mono, di- or tri- substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, processes for preparing the compounds and new intermediates useful in the process.

Siderophore Analogues. Synthesis and Chelating Properties of a New Macrocyclic Trishydroxamate Ligand

A new iron(III)-specific ligand, 1,5,9-triazacyclododecane-N,N',N''-tris(N-methylacetohydroxamic acid) H3L, containing three hydroxamic acid groups as pendant arms on a macrocyclic triamine backbone, has been synthesized and characterized.Its acid-base an

Reactions of α-Hydroxy Carbonyl Compounds with Azodicarboxylates and Triphenylphosphine: Synthesis of α-N-Hydroxy Amino Acid Derivatives

Reaction of aliphatic α-hydroxy esters with azodicarboxylates and triphenylphosphine in the presence of either CbzNHOCH2Ph or trOCNHOCH2Ph provides a direct route to protected α-N-hydroxy amino acids.Similar reactions with aromatic α-hydroxy carbonyl compounds and derivatives result in predominate oxidation to the corresponding α-oxo carbonyl derivatives.

Constituents of Microbial Iron Chelators. Alternate Syntheses of δ-N-Hydroxy-L-ornithine Derivatives and Applications to the Synthesis of Rhodotorulic Acid

δ-N-Hydroxy-L-ornithine derivatives, the key constituents of several microbial iron chelators, have been prepared from protected forms of L-glutamic acid.Reduction of α-tert-butyl N-Boc-glutamate (3) provided α-tert-butyl L-N-Boc-δ-hydroxynorvaline (4).Direct treatment of 4 with Cbz-O-benzylhydroxylamine (5) or trOC-O-benzylhydroxylamine (6) gave the protected δ-N-hydroxyornithine derivatives 7 and 8, respectively. δ-N-Deprotection followed by acetylation provided α-tert-butyl-L-N-Boc-δ-N-acetyl-δ-N-benzyloxyornithine (9).Appropriate α-amino and α-carboxyl deprotections of 8 and 9 provided derivatives of δ-N-hydroxy-L-ornithine suitable for the synthesis of rhodotorulic acid (24) by two routes.The first route employed conventional peptide synthesis methods.The second synthesis or rhodotorulic acid involved the direct dimerization of Leuch's anhydrides 25 and 26 derived from the δ-N-acetyl- and δ-N-trOC-δ-N-benzyloxyornithines 11 and 16.