1-benzyl-4-aminopiperidine hydrobromide

Base Information

• Chemical Name: 1-benzyl-4-aminopiperidine hydrobromide
• CAS No.: 79098-97-8
• Molecular Formula: BrH*C₂₀H₂₃N₃O₃
• Molecular Weight: 434.333
• Mol file: 79098-97-8.mol

Synonyms:

Chemical Property of 1-benzyl-4-aminopiperidine hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-4-aminopiperidine hydrobromide

There total 1 articles about 1-benzyl-4-aminopiperidine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

Acetyl bromide (506-96-7) + 1-benzyl-4-(2-nitrophenyl)aminopiperidine hydrochloride (63003-77-0) → 1-benzyl-4-aminopiperidine hydrobromide (79098-97-8)

Guidance literature:

In 1,4-dioxane; for 3h; Heating;

DOI:10.1002/jhet.5570200315

Reference yield:

1-benzyl-4-aminopiperidine hydrobromide (79098-97-8) → 1-(3,4-Dimethoxy-phenyl)-2-[4-(2-methyl-benzoimidazol-1-yl)-piperidin-1-yl]-propan-1-ol (79122-24-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) H₂; 2) conc. HCl / Pd/C / 1) 20 deg C, 5 h; 2) 12 h

2: 80 percent / triethylamine / methanol / 20 °C

3: NaBH₄ / ethanol / 1.5 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1002/jhet.5570200315

Reference yield:

1-benzyl-4-aminopiperidine hydrobromide (79098-97-8) → 1-(3,4-Dimethoxy-phenyl)-2-[4-(2-methyl-benzoimidazol-1-yl)-piperidin-1-yl]-ethanone (79106-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) H₂; 2) conc. HCl / Pd/C / 1) 20 deg C, 5 h; 2) 12 h

2: 61 percent / triethylamine / methanol / 20 °C

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol;

DOI:10.1002/jhet.5570200315

upstream raw materials:

Acetyl bromide

1-benzyl-4-(2-nitrophenyl)aminopiperidine hydrochloride

Downstream raw materials:

1-(3,4-Dimethoxy-phenyl)-2-[4-(2-methyl-benzoimidazol-1-yl)-piperidin-1-yl]-ethanone

1-(3,4-Dimethoxy-phenyl)-2-[4-(2-methyl-benzoimidazol-1-yl)-piperidin-1-yl]-propan-1-one

1-(3,4-Dimethoxy-phenyl)-2-[4-(2-methyl-benzoimidazol-1-yl)-piperidin-1-yl]-ethanol

1-(3,4-Dimethoxy-phenyl)-2-[4-(2-methyl-benzoimidazol-1-yl)-piperidin-1-yl]-propan-1-ol