(2S,4R)-4-((2R,3R,4aR,5S,7R,8S,8aS)-8-Hydroxy-2,3,5-trimethoxy-2,3-dimethyl-hexahydro-pyrano[3,4-b][1,4]dioxin-7-ylmethoxycarbonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester 2-pentafluorophenyl ester

Base Information

Chemical Name:(2S,4R)-4-((2R,3R,4aR,5S,7R,8S,8aS)-8-Hydroxy-2,3,5-trimethoxy-2,3-dimethyl-hexahydro-pyrano[3,4-b][1,4]dioxin-7-ylmethoxycarbonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester 2-pentafluorophenyl ester
CAS No.:683210-94-8
Molecular Formula:C₄₀H₄₀F₅NO₁₄
Molecular Weight:853.748
Hs Code.:

(2S,4R)-4-((2R,3R,4aR,5S,7R,8S,8aS)-8-Hydroxy-2,3,5-trimethoxy-2,3-dimethyl-hexahydro-pyrano[3,4-b][1,4]dioxin-7-ylmethoxycarbonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester 2-pentafluorophenyl ester

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Chemical Property of (2S,4R)-4-((2R,3R,4aR,5S,7R,8S,8aS)-8-Hydroxy-2,3,5-trimethoxy-2,3-dimethyl-hexahydro-pyrano[3,4-b][1,4]dioxin-7-ylmethoxycarbonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester 2-pentafluorophenyl ester

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Technology Process of (2S,4R)-4-((2R,3R,4aR,5S,7R,8S,8aS)-8-Hydroxy-2,3,5-trimethoxy-2,3-dimethyl-hexahydro-pyrano[3,4-b][1,4]dioxin-7-ylmethoxycarbonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester 2-pentafluorophenyl ester

There total 3 articles about (2S,4R)-4-((2R,3R,4aR,5S,7R,8S,8aS)-8-Hydroxy-2,3,5-trimethoxy-2,3-dimethyl-hexahydro-pyrano[3,4-b][1,4]dioxin-7-ylmethoxycarbonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester 2-pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-44-5
phosgene

: 147836-79-1
N^α-(fluoren-9-ylmethoxycarbonyl)-L-trans-hydroxyproline pentafluorophenyl ester

: 176897-11-3
(2'R,3'R)-methyl-2,3-O-(2',3'-dimethoxybutane-2',3'-diyl)-a-D-galactopyranoside

: 683210-94-8
(2S,4R)-4-((2R,3R,4aR,5S,7R,8S,8aS)-8-Hydroxy-2,3,5-trimethoxy-2,3-dimethyl-hexahydro-pyrano[3,4-b][1,4]dioxin-7-ylmethoxycarbonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester 2-pentafluorophenyl ester

Guidance literature:: phosgene; N^α-(fluoren-9-ylmethoxycarbonyl)-L-trans-hydroxyproline pentafluorophenyl ester; In tetrahydrofuran; toluene; at -78 - 20 ℃;

(2'R,3'R)-methyl-2,3-O-(2',3'-dimethoxybutane-2',3'-diyl)-a-D-galactopyranoside; In tetrahydrofuran; toluene; at -78 - 20 ℃;
DOI:10.1002/1521-3773(20020402)41:7<1215::AID-ANIE1215>3.0.CO;2-V

Reference yield:

: 147836-79-1
N^α-(fluoren-9-ylmethoxycarbonyl)-L-trans-hydroxyproline pentafluorophenyl ester

: 683210-94-8
(2S,4R)-4-((2R,3R,4aR,5S,7R,8S,8aS)-8-Hydroxy-2,3,5-trimethoxy-2,3-dimethyl-hexahydro-pyrano[3,4-b][1,4]dioxin-7-ylmethoxycarbonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester 2-pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / -78 - 20 °C

2: pyridine / CH₂Cl₂

With pyridine; In dichloromethane;
DOI:10.1039/b313571c