C₂₁H₁₈FN₅O₄

Base Information

Chemical Name:C₂₁H₁₈FN₅O₄
CAS No.:959321-17-6
Molecular Formula:C₂₁H₁₈FN₅O₄
Molecular Weight:423.403
Hs Code.:

C<sub>21</sub>H<sub>18</sub>FN<sub>5</sub>O<sub>4</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₁H₁₈FN₅O₄

Chemical Property:

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Technology Process of C₂₁H₁₈FN₅O₄

There total 9 articles about C₂₁H₁₈FN₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₀H₆FN₃O₄

: 56227-55-5,79332-89-1
N-benzoylpiperazine hydrochloride

: 959321-17-6
C₂₁H₁₈FN₅O₄

Guidance literature:: With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/jm3016377

Reference yield:

: C₈H₆FN₃O

: 959321-17-6
C₂₁H₁₈FN₅O₄

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride / 48 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere; Cooling with ice

2.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; aluminum (III) chloride; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm3016377

Reference yield:

: 51173-04-7
5-fluoro-2-methoxypyridine

: 959321-17-6
C₂₁H₁₈FN₅O₄

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / toluene / 2 h / Inert atmosphere; Sealed tube; Heating

2.1: sulfuric acid; nitric acid / 1 h / 20 - 80 °C / Inert atmosphere

3.1: tetrahydrofuran / 2.25 h / Inert atmosphere; Cooling

4.1: N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere; Sealed tube

5.1: sodium hydroxide / ethanol / 18 h / Inert atmosphere; Sealed tube; Heating

5.2: 20 °C / pH 2 / Inert atmosphere; Sealed tube

6.1: 4-methylmorpholine N-oxide; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 20 °C / Inert atmosphere

7.1: aluminum (III) chloride; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride / 48 h / 20 °C / Inert atmosphere

7.2: Inert atmosphere; Cooling with ice

8.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; aluminum (III) chloride; sulfuric acid; nitric acid; ammonium chloride; 4-methylmorpholine N-oxide; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; 3.1: |Bartoli Indole Synthesis;
DOI:10.1021/jm3016377