N'-(9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,5-dihydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine

Base Information

• Chemical Name: N'-(9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,5-dihydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine
• CAS No.: 181508-24-7
• Molecular Formula: C₃₄H₃₄N₆O₅
• Molecular Weight: 606.681
• Mol file: 181508-24-7.mol

Synonyms:

Chemical Property of N'-(9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,5-dihydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,5-dihydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine

There total 5 articles about N'-(9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,5-dihydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N'-(9-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-thioxo-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine → N'-(9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,5-dihydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine (181508-24-7)

Guidance literature:

With triethyl phosphite; In toluene; at 145 - 150 ℃; for 4.5h;

DOI:10.1080/07328319608002427

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → N'-(9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,5-dihydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine (181508-24-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / dimethylformamide; pyridine / 36 h / Ambient temperature

2: CH₂Cl₂ / 2.5 h / Ambient temperature

3: 0.82 g / (EtO)3P / toluene / 4.5 h / 145 - 150 °C

With triethyl phosphite; In pyridine; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1080/07328319608002427

Reference yield:

isoguanosine (1818-71-9) → N'-(9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,5-dihydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine (181508-24-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / dimethylformamide / 24 h / Ambient temperature

2: 62 percent / dimethylformamide; pyridine / 36 h / Ambient temperature

3: CH₂Cl₂ / 2.5 h / Ambient temperature

4: 0.82 g / (EtO)3P / toluene / 4.5 h / 145 - 150 °C

With triethyl phosphite; In pyridine; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1080/07328319608002427

upstream raw materials:

4,4'-dimethoxytrityl chloride

isoguanosine

N'-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-3,9-dihydro-2H-purin-6-yl]-N,N-dimethyl-formamidine

N'-(9-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine

Downstream raw materials:

6-Amino-9-{(2R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,5-dihydro-furan-2-yl}-3,9-dihydro-purin-2-one