N'-(9-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine

Base Information

• Chemical Name: N'-(9-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine
• CAS No.: 151059-70-0
• Molecular Formula: C₃₄H₃₆N₆O₇
• Molecular Weight: 640.696
• Mol file: 151059-70-0.mol

Synonyms:

Chemical Property of N'-(9-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(9-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine

There total 3 articles about N'-(9-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N'-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-3,9-dihydro-2H-purin-6-yl]-N,N-dimethyl-formamidine (156706-72-8) → N'-(9-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine (151059-70-0)

Guidance literature:

In pyridine; N,N-dimethyl-formamide; for 36h; Ambient temperature;

DOI:10.1080/07328319608002427

Reference yield:

isoguanosine (1818-71-9) → N'-(9-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine (151059-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / dimethylformamide / 24 h / Ambient temperature

2: 62 percent / dimethylformamide; pyridine / 36 h / Ambient temperature

In pyridine; N,N-dimethyl-formamide;

DOI:10.1080/07328319608002427

Reference yield:

adenosine-2-amine (2096-10-8) → N'-(9-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine (151059-70-0)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium nitrite; acetic acid / water

2: N,N-dimethyl-formamide

3: pyridine

With pyridine; lithium nitrite; acetic acid; In water; N,N-dimethyl-formamide;

DOI:10.1371/journal.pone.0197835

upstream raw materials:

4,4'-dimethoxytrityl chloride

N'-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-3,9-dihydro-2H-purin-6-yl]-N,N-dimethyl-formamidine

isoguanosine

adenosine-2-amine

Downstream raw materials:

6-Amino-9-{(2R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,5-dihydro-furan-2-yl}-3,9-dihydro-purin-2-one

N'-(9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,5-dihydro-furan-2-yl}-2-oxo-3,9-dihydro-2H-purin-6-yl)-N,N-dimethyl-formamidine