N-(t-butyloxycarbonyl)aminodihydroisoindole

Base Information

• Chemical Name: N-(t-butyloxycarbonyl)aminodihydroisoindole
• CAS No.: 131762-67-9
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234.298
• Mol file: 131762-67-9.mol

Synonyms:

Chemical Property of N-(t-butyloxycarbonyl)aminodihydroisoindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(t-butyloxycarbonyl)aminodihydroisoindole

There total 2 articles about N-(t-butyloxycarbonyl)aminodihydroisoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

t-butoxycarbonylhydrazine (870-46-2) + α,α'-dibromo-o-xylene (91-13-4) → N-(t-butyloxycarbonyl)aminodihydroisoindole (131762-67-9) + tert-butyl 2,2′-(1,2-phenylenebis(methylene))bis(hydrazinecarboxylate) (1174920-64-9)

Guidance literature:

t-butoxycarbonylhydrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -45 ℃; for 0.25h; Inert atmosphere;

α,α'-dibromo-o-xylene; In tetrahydrofuran; hexane; at -45 ℃; for 0.166667h; Concentration; Inert atmosphere;

DOI:10.1021/om4009394

Reference yield: 8.0%

t-butoxycarbonylhydrazine (870-46-2) + o-Xylylene dichloride (612-12-4) → N-(t-butyloxycarbonyl)aminodihydroisoindole (131762-67-9) + tert-butyl 2,2′-(1,2-phenylenebis(methylene))bis(hydrazinecarboxylate) (1174920-64-9)

Guidance literature:

t-butoxycarbonylhydrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -45 ℃; for 0.25h; Inert atmosphere;

o-Xylylene dichloride; In tetrahydrofuran; hexane; at -45 ℃; for 24h; Inert atmosphere;

DOI:10.1021/om4009394

Reference yield:

N-(t-butyloxycarbonyl)aminodihydroisoindole (131762-67-9) → 2-amino-isoindoline (21507-95-9)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

t-butoxycarbonylhydrazine

α,α'-dibromo-o-xylene

o-Xylylene dichloride

Downstream raw materials:

2-amino-isoindoline

N-aminodihydroisoindole hydrochloride

N-benzylideneaminodihydroisoindole

N-(o-hydroxybenzylidene)aminodihydroisoindole