Technology Process of 1,1-Bis-[3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-4-yl]-ethanol
There total 2 articles about 1,1-Bis-[3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-4-yl]-ethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 20 percent aq. NaOH / methanol / 0.17 h / Heating
2: 1.) lithium diisopropylamide, hexamethylphosphoric triamide / 1.) THF, hexane, -78 deg C, 2 h, 2.) -78 deg C, 2.5 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; lithium diisopropyl amide;
In
methanol;
- Guidance literature:
-
With
N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;
Yield given. Multistep reaction. Yields of byproduct given;
1.) THF, hexane, -78 deg C, 2 h, 2.) -78 deg C, 2.5 h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 20 percent aq. NaOH / methanol / 0.17 h / Heating
2: 1.) lithium diisopropylamide, hexamethylphosphoric triamide / 1.) THF, hexane, -78 deg C, 2 h, 2.) -78 deg C, 2.5 h
3: K2Cr2O7, H2SO4 / diethyl ether / 1.25 h / 0 °C
4: 97 percent / active MnO2 / benzene / 1 h / Heating
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium dichromate; manganese(IV) oxide; sodium hydroxide; sulfuric acid; lithium diisopropyl amide;
In
methanol; diethyl ether; benzene;