p-broMoxylylphthaliMide

Base Information

• Chemical Name: p-broMoxylylphthaliMide
• CAS No.: 101367-16-2
• Molecular Formula: C16H12BrNO2
• Molecular Weight: 330.181
• Mol file: 101367-16-2.mol

Synonyms:2-{[4-(bromomethyl)phenyl]methyl}-1H-isoindole-1,3(2H)-dione;2-[4-(bromomethyl)benzyl]isoindoline-1,3-dione;4-phthalimidomethylbenzyl bromide;2-(4-Bromomethyl-benzyl)-isoindole-1,3-dione;2-(4-(bromomethyl)benzyl)isoindoline-1,3-dione;

Chemical Property of p-broMoxylylphthaliMide

Chemical Property:

• PSA: 37.38000
• LogP: 3.31560

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of p-broMoxylylphthaliMide

There total 7 articles about p-broMoxylylphthaliMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1,4-bis(bromomethyl)benzene (623-24-5) + phthalimide (136918-14-4,85-41-6) → 2-{[4-(bromomethyl)phenyl]methyl}-1H-isoindole-1,3(2H)-dione (101367-16-2)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In acetonitrile; at 25 ℃; for 18h; Inert atmosphere;

DOI:10.1039/c7ob02347b

Reference yield: 60.0%

2-(4-(hydroxymethyl)benzyl)isoindoline-1,3-dione (439691-95-9) → 2-{[4-(bromomethyl)phenyl]methyl}-1H-isoindole-1,3(2H)-dione (101367-16-2)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 25 ℃;

Reference yield: 32.0%

1,4-bis(bromomethyl)benzene (623-24-5) + phthalimide (136918-14-4,85-41-6) → α,α-4-bis(1H-isoindol-1,3(2H)-dione)xylene (30391-55-0) + 2-{[4-(bromomethyl)phenyl]methyl}-1H-isoindole-1,3(2H)-dione (101367-16-2)

Guidance literature:

phthalimide; With potassium carbonate; for 1h; Milling;

1,4-bis(bromomethyl)benzene; In N,N-dimethyl-formamide; for 1h; regioselective reaction; Milling;

DOI:10.3762/bjoc.13.169

upstream raw materials:

1,4-bis(bromomethyl)benzene

potassium phtalimide

2-(4-methylbenzyl)-1H-isoindol-1,3(2H)-dione

2-(4-(hydroxymethyl)benzyl)isoindoline-1,3-dione

Downstream raw materials:

[6-(4-Aminomethyl-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester

6-{[4-({[N,N'-bis[(1,1-dimethylethoxy)carbonyl]aminoiminomethyl]amino}methyl)phenyl]methoxy}-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester

[4-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)phenyl]acetonitrile

1-(p-phthalimidoxylyl)-4,7-bis(tert-butoxycarbonyl)-1,4,7-triazacyclononane