2-(4-Fluoro-phenyl)-1-((2R,6R,11R)-8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl)-ethanone

Base Information

• Chemical Name: 2-(4-Fluoro-phenyl)-1-((2R,6R,11R)-8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl)-ethanone
• CAS No.: 86436-93-3
• Molecular Formula: C₂₂H₂₄FNO₂
• Molecular Weight: 353.436
• Mol file: 86436-93-3.mol

Synonyms:

Chemical Property of 2-(4-Fluoro-phenyl)-1-((2R,6R,11R)-8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl)-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Fluoro-phenyl)-1-((2R,6R,11R)-8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl)-ethanone

There total 1 articles about 2-(4-Fluoro-phenyl)-1-((2R,6R,11R)-8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-cis-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan (52079-30-8) + 4-Fluorophenylacetyl chloride (459-04-1) → 2-(4-Fluoro-phenyl)-1-((2R,6R,11R)-8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl)-ethanone (86436-93-3)

Guidance literature:

With potassium carbonate; In methanol;

DOI:10.1021/jm00365a017

Reference yield:

2-(4-Fluoro-phenyl)-1-((2R,6R,11R)-8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl)-ethanone (86436-93-3) → fluorophen (86495-14-9)

Guidance literature:

With hydrogenchloride; diborane; Yield given. Multistep reaction; 1.) THF, reflux, 2 h, 2.) MeOH, heating, 1 h;

DOI:10.1021/jm00365a017

upstream raw materials:

(+/-)-cis-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan

4-Fluorophenylacetyl chloride

Downstream raw materials:

fluorophen