N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}-2-{4-[2-({2-[(tert-butyldiphenylsilyl)oxy]ethyl}(1-methyl-1-phenylethyl)carbamoyl)-4-chlorophenyl]-3-oxobutyl}-N-(1-ethylcyclopentyl)benzamide

Base Information

• Chemical Name: N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}-2-{4-[2-({2-[(tert-butyldiphenylsilyl)oxy]ethyl}(1-methyl-1-phenylethyl)carbamoyl)-4-chlorophenyl]-3-oxobutyl}-N-(1-ethylcyclopentyl)benzamide
• CAS No.: 1027141-71-4
• Molecular Formula: C₇₀H₈₃ClN₂O₅Si₂
• Molecular Weight: 1124.06

Synonyms:

Chemical Property of N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}-2-{4-[2-({2-[(tert-butyldiphenylsilyl)oxy]ethyl}(1-methyl-1-phenylethyl)carbamoyl)-4-chlorophenyl]-3-oxobutyl}-N-(1-ethylcyclopentyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}-2-{4-[2-({2-[(tert-butyldiphenylsilyl)oxy]ethyl}(1-methyl-1-phenylethyl)carbamoyl)-4-chlorophenyl]-3-oxobutyl}-N-(1-ethylcyclopentyl)benzamide

There total 12 articles about N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}-2-{4-[2-({2-[(tert-butyldiphenylsilyl)oxy]ethyl}(1-methyl-1-phenylethyl)carbamoyl)-4-chlorophenyl]-3-oxobutyl}-N-(1-ethylcyclopentyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethylcyclopentan-1-amine (67404-87-9) → N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}-2-{4-[2-({2-[(tert-butyldiphenylsilyl)oxy]ethyl}(1-methyl-1-phenylethyl)carbamoyl)-4-chlorophenyl]-3-oxobutyl}-N-(1-ethylcyclopentyl)benzamide (1027141-71-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) LiClO₄ / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₃CN, RT, 3 h

2: imidazole / CH₂Cl₂ / 18 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 21 h / Ambient temperature

4: 1.) diisopropylamine, sec-butyllithium / 1.) THF, -70 deg C, 1.5 h, 2.) THF, RT, 16 h

5: Jone's reagent / acetone

6: DEPC, diisopropylethylamine / CH₂Cl₂ / 2 h / Ambient temperature

7: 1.) diisopropylamine, sec-butyllithium / 1.) THF, -78 deg C, 50 min, 2.) THF, from -78 deg C to RT, 17.5 h

With 1H-imidazole; Jones reagent; sec.-butyllithium; lithium perchlorate; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; diethyl dicarbonate; In dichloromethane; acetone;

DOI:10.1021/jm960092w

Reference yield:

5-chloro-2-methylbenzoic acid (7499-06-1) → N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}-2-{4-[2-({2-[(tert-butyldiphenylsilyl)oxy]ethyl}(1-methyl-1-phenylethyl)carbamoyl)-4-chlorophenyl]-3-oxobutyl}-N-(1-ethylcyclopentyl)benzamide (1027141-71-4)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl chloride, DMF / toluene / 0.67 h / Ambient temperature

2: Et₃N / tetrahydrofuran

3: 1.) diisopropylamine, sec-butyllithium / 1.) THF, -78 deg C, 50 min, 2.) THF, from -78 deg C to RT, 17.5 h

With oxalyl dichloride; sec.-butyllithium; triethylamine; diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;

DOI:10.1021/jm960092w

Reference yield:

5-chloro-2-methylbenzoyl chloride (21900-40-3) → N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}-2-{4-[2-({2-[(tert-butyldiphenylsilyl)oxy]ethyl}(1-methyl-1-phenylethyl)carbamoyl)-4-chlorophenyl]-3-oxobutyl}-N-(1-ethylcyclopentyl)benzamide (1027141-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran

2: 1.) diisopropylamine, sec-butyllithium / 1.) THF, -78 deg C, 50 min, 2.) THF, from -78 deg C to RT, 17.5 h

With sec.-butyllithium; triethylamine; diisopropylamine; In tetrahydrofuran;

DOI:10.1021/jm960092w

upstream raw materials:

N-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-chloro-2-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide

N-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-N-(1-ethyl-cyclopentyl)-2-[2-(methoxy-methyl-carbamoyl)-ethyl]-benzamide

1-ethylcyclopentan-1-amine

5-chloro-2-methylbenzoic acid

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