7499-06-1

Basic information

• Product Name: 5-Chloro-2-methylbenzoic acid
• Synonyms: 3-CHLORO-6-METHYLBENZOIC ACID;5-CHLORO-2-METHYLBENZOIC ACID;5-CHLORO-O-TOLUIC ACID;RARECHEM AL BO 0471;5-Chloro-2-methylbenzoic;4-(CHLOROMETHYL)BENZOIC ACID 99+%;5-Chloro-o-toluic acid, 2-Carboxy-4-chlorotoluene;o-Toluic acid, 5-chloro-
• CAS NO: 7499-06-1
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.59
• Product Categories: Acids and Derivatives;Aromatic Nitriles;Benzoic acid;Organic acids;C7;Carbonyl Compounds;Carboxylic Acids;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
• Mol File: 7499-06-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 168 °C
• Boiling Point: 293.5 °C at 760 mmHg
• Flash Point: 131.3 °C
• Appearance: /
• Density: 1.31 g/cm³
• Vapor Pressure: 0.000782mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 3.50±0.25(Predicted)
• CAS DataBase Reference: 5-Chloro-2-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-methylbenzoic acid(7499-06-1)
• EPA Substance Registry System: 5-Chloro-2-methylbenzoic acid(7499-06-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 7499-06-1(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C8H7ClO2/c1-5-2-3-6(9)4-7(5)8(10)11/h2-4H,1H3,(H,10,11)

Upstream product

• 118-90-1 ortho-methylbenzoic acid 
• 50712-70-4 5-chloro-2-methylbenzonitrile 
• 98588-89-7 5,β,β-trichloro-2-methyl-styrene 
• 69773-58-6 Dimethyl-(5-chlor-2-methyl-benzyl)-amin 
• 124-38-9 carbon dioxide 
• 95-73-8 2,4-dichlorotoluene 
• 18964-63-1 2-Methyl-5-chlor-benzotrichlorid 
• 7782-50-5 chlorine 
• 64-19-7 acetic acid 
• 67-66-3 chloroform 
• 103039-12-9 2-methyl-4-methoxy-5-chloracetophenone 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 95-79-4 5-chloro-2-methyl-benzenamine 
• 615-60-1 4-chloro-1,2-dimethylbenzene 

Downstream Products

• 89-20-3 4-chlorophthalic acid 
• 21900-40-3 5-chloro-2-methylbenzoyl chloride 
• 99585-13-4 methyl 2-methyl-5-chlorobenzoate 
• 33886-49-6 6-chloro-2-phenylisoindolin-1-one 
• 1224944-62-0 5-chloro-N-(3-(5-chloro-2-methylphenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1224944-61-9 5-(5-chloro-2-methylphenyl)-1-methyl-1H-pyrazol-4-amine 
• 1224944-60-8 3-(5-chloro-2-methylphenyl)-1-methyl-1H-pyrazol-4-amine 
• 1224942-00-0 5-amino-N-(3-(5-chloro-2-methylphenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 

Relevant articles and documents

HYDANTOIN DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISORDERS

This invention relates to compounds of Formula (1) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF- or combinations thereof.

Electrosynthesis of aryl-carboxylic acids from chlorobenzene derivatives and carbon dioxide

The electrocarboxylation of a large variety of chlorobenzenic compounds is achieved in N,N-dimethylformamide by constant current electrolysis between a stainless steel cathode and a sacrificial magnesium anode in a diaphragmless cell. Substituted benzoic acids are obtained in high yield in simle conditions thus avoiding the usual preparation of organometallic intermediates.