Technology Process of [5-Benzyloxycarbonylamino-2-(4-formylamino-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetic acid
There total 7 articles about [5-Benzyloxycarbonylamino-2-(4-formylamino-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium chlorite; sodium dihydrogenphosphate;
In
tetrahydrofuran; tert-butyl alcohol;
for 1h;
Ambient temperature;
DOI:10.1021/jm00001a015
- Guidance literature:
-
Multi-step reaction with 7 steps
1: HCl / ethanol / 16 h / Ambient temperature
2: methanol / 72 h / 5 °C
3: methanol / 1.5 h / 100 °C
4: pyridine, lithium iodide / 2 h / Heating
5: 1.) Et3N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h
6: 1N aq. HCl / tetrahydrofuran / 8 h / Heating
7: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s) / 1 h / Ambient temperature
With
pyridine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; diphenyl phosphoryl azide; triethylamine; lithium iodide;
In
tetrahydrofuran; methanol; ethanol; tert-butyl alcohol;
DOI:10.1021/jm00001a015
- Guidance literature:
-
Multi-step reaction with 5 steps
1: methanol / 1.5 h / 100 °C
2: pyridine, lithium iodide / 2 h / Heating
3: 1.) Et3N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h
4: 1N aq. HCl / tetrahydrofuran / 8 h / Heating
5: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s) / 1 h / Ambient temperature
With
pyridine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; diphenyl phosphoryl azide; triethylamine; lithium iodide;
In
tetrahydrofuran; methanol; tert-butyl alcohol;
DOI:10.1021/jm00001a015