tert-Butyl-[(1R,2S,4R)-6-(diphenyl-phosphinoyl)-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-dimethyl-silane

Base Information

Chemical Name:tert-Butyl-[(1R,2S,4R)-6-(diphenyl-phosphinoyl)-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-dimethyl-silane
CAS No.:118227-60-4
Molecular Formula:C₃₆H₅₉O₄PS₂Si
Molecular Weight:679.053
Hs Code.:

tert-Butyl-[(1R,2S,4R)-6-(diphenyl-phosphinoyl)-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-dimethyl-silane

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Chemical Property of tert-Butyl-[(1R,2S,4R)-6-(diphenyl-phosphinoyl)-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-dimethyl-silane

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Technology Process of tert-Butyl-[(1R,2S,4R)-6-(diphenyl-phosphinoyl)-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-dimethyl-silane

There total 22 articles about tert-Butyl-[(1R,2S,4R)-6-(diphenyl-phosphinoyl)-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,2-Dimethyl-propionic acid (2R,4S,5R,6S,8R)-9-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-6-methoxy-2,8-dimethyl-5-phenylacetoxy-nonyl ester

: 118227-60-4,126922-98-3,126922-99-4
tert-Butyl-[(1R,2S,4R)-6-(diphenyl-phosphinoyl)-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1: NaH / tetrahydrofuran / 0 °C

2: H₂ / Pd(OH)2 / ethyl acetate

3: 2,6-lutidine / CH₂Cl₂

4: TFA / H₂O; tetrahydrofuran / 20 °C

6: pyridine / 0 °C

7: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) 0 deg C

With 2,6-dimethylpyridine; n-butyllithium; hydrogen; sodium hydride; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; pyridine; dichloromethane; water; ethyl acetate;
DOI:10.1021/ja00185a071

Reference yield:

: Phenyl-acetic acid (1R,2S,4R)-5-(tert-butyl-dimethyl-silanyloxy)-1-((1S,3R)-1,4-dihydroxy-3-methyl-butyl)-2-methoxy-4-methyl-pentyl ester

: 118227-60-4,126922-98-3,126922-99-4
tert-Butyl-[(1R,2S,4R)-6-(diphenyl-phosphinoyl)-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine / 0 °C

2: NaH / tetrahydrofuran / 0 °C

3: H₂ / Pd(OH)2 / ethyl acetate

4: 2,6-lutidine / CH₂Cl₂

5: TFA / H₂O; tetrahydrofuran / 20 °C

7: pyridine / 0 °C

8: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) 0 deg C

With 2,6-dimethylpyridine; n-butyllithium; hydrogen; sodium hydride; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; pyridine; dichloromethane; water; ethyl acetate;
DOI:10.1021/ja00185a071

Reference yield:

: 2,2-Dimethyl-propionic acid (2R,4S,5R,6S,8R)-9-(tert-butyl-dimethyl-silanyloxy)-4,6-dimethoxy-2,8-dimethyl-5-phenylacetoxy-nonyl ester

: 118227-60-4,126922-98-3,126922-99-4
tert-Butyl-[(1R,2S,4R)-6-(diphenyl-phosphinoyl)-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd(OH)2 / ethyl acetate

2: 2,6-lutidine / CH₂Cl₂

3: TFA / H₂O; tetrahydrofuran / 20 °C

5: pyridine / 0 °C

6: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) 0 deg C

With 2,6-dimethylpyridine; n-butyllithium; hydrogen; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; pyridine; dichloromethane; water; ethyl acetate;
DOI:10.1021/ja00185a071