Benzenesulfonic acid (2R,4S,5R,6S,8R)-5-(tert-butyl-dimethyl-silanyloxy)-8-[1,3]dithian-2-yl-4,6-dimethoxy-2-methyl-nonyl ester

Base Information

Chemical Name:Benzenesulfonic acid (2R,4S,5R,6S,8R)-5-(tert-butyl-dimethyl-silanyloxy)-8-[1,3]dithian-2-yl-4,6-dimethoxy-2-methyl-nonyl ester
CAS No.:126789-02-4
Molecular Formula:C₂₈H₅₀O₆S₃Si
Molecular Weight:606.985
Hs Code.:

Synonyms:Benzenesulfonic acid (2R,4S,5R,6S,8R)-5-(tert-butyl-dimethyl-silanyloxy)-8-[1,3]dithian-2-yl-4,6-dimethoxy-2-methyl-nonyl ester

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Chemical Property of Benzenesulfonic acid (2R,4S,5R,6S,8R)-5-(tert-butyl-dimethyl-silanyloxy)-8-[1,3]dithian-2-yl-4,6-dimethoxy-2-methyl-nonyl ester

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Technology Process of Benzenesulfonic acid (2R,4S,5R,6S,8R)-5-(tert-butyl-dimethyl-silanyloxy)-8-[1,3]dithian-2-yl-4,6-dimethoxy-2-methyl-nonyl ester

There total 13 articles about Benzenesulfonic acid (2R,4S,5R,6S,8R)-5-(tert-butyl-dimethyl-silanyloxy)-8-[1,3]dithian-2-yl-4,6-dimethoxy-2-methyl-nonyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 118949-46-5
(2R,4S,5R,6S,8R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-[1,3]dithian-2-yl-4,6-dimethoxy-2-methyl-nonan-1-ol

: 98-09-9
benzenesulfonyl chloride

: 126789-02-4
Benzenesulfonic acid (2R,4S,5R,6S,8R)-5-(tert-butyl-dimethyl-silanyloxy)-8-[1,3]dithian-2-yl-4,6-dimethoxy-2-methyl-nonyl ester

Guidance literature:: With pyridine; 1.) 0 deg C, 1 h, 2.) -30 deg C, 15 h;
DOI:10.1021/ja00164a023

Reference yield:

: Phenyl-acetic acid (1R,2S,4R)-5-(tert-butyl-dimethyl-silanyloxy)-1-((1S,3R)-1,4-dihydroxy-3-methyl-butyl)-2-methoxy-4-methyl-pentyl ester

: 126789-02-4
Benzenesulfonic acid (2R,4S,5R,6S,8R)-5-(tert-butyl-dimethyl-silanyloxy)-8-[1,3]dithian-2-yl-4,6-dimethoxy-2-methyl-nonyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / 0 °C

2: NaH / tetrahydrofuran / 0 °C

3: H₂ / Pd(OH)2 / ethyl acetate

4: 2,6-lutidine / CH₂Cl₂

5: TFA / H₂O; tetrahydrofuran / 20 °C

7: pyridine / 0 °C

With 2,6-dimethylpyridine; hydrogen; sodium hydride; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; pyridine; dichloromethane; water; ethyl acetate;
DOI:10.1021/ja00185a071

Reference yield:

: 2,2-Dimethyl-propionic acid (2R,4S,5R,6S,8R)-9-(tert-butyl-dimethyl-silanyloxy)-4,6-dimethoxy-2,8-dimethyl-5-phenylacetoxy-nonyl ester

: 126789-02-4
Benzenesulfonic acid (2R,4S,5R,6S,8R)-5-(tert-butyl-dimethyl-silanyloxy)-8-[1,3]dithian-2-yl-4,6-dimethoxy-2-methyl-nonyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd(OH)2 / ethyl acetate

2: 2,6-lutidine / CH₂Cl₂

3: TFA / H₂O; tetrahydrofuran / 20 °C

5: pyridine / 0 °C

With 2,6-dimethylpyridine; hydrogen; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; pyridine; dichloromethane; water; ethyl acetate;
DOI:10.1021/ja00185a071