((1S,6R,7S)-9-Benzyl-9-aza-bicyclo[4.2.1]non-7-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

Base Information

• Chemical Name: ((1S,6R,7S)-9-Benzyl-9-aza-bicyclo[4.2.1]non-7-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone
• CAS No.: 446873-03-6
• Molecular Formula: C₂₆H₃₆N₂O₃S
• Molecular Weight: 456.649

Synonyms:

Chemical Property of ((1S,6R,7S)-9-Benzyl-9-aza-bicyclo[4.2.1]non-7-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1S,6R,7S)-9-Benzyl-9-aza-bicyclo[4.2.1]non-7-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

There total 7 articles about ((1S,6R,7S)-9-Benzyl-9-aza-bicyclo[4.2.1]non-7-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hexamethylene imine (111-49-9) → ((1S,6R,7S)-9-Benzyl-9-aza-bicyclo[4.2.1]non-7-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone (446873-03-6)

Guidance literature:

Multi-step reaction with 6 steps

1: dioxane

2: 80 percent / TMEDA; s-BuLi / -78 °C

3: 62 percent / TMEDA; s-BuLi / 5 h / -40 °C

4: 100 percent / TFA / CH₂Cl₂

5: K₂CO₃ / acetonitrile

6: AgF / CH₂Cl₂ / 6 h

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; silver fluoride; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; acetonitrile;

DOI:10.1016/S0040-4020(02)00322-8

Reference yield:

benzyl bromide (100-39-0) → ((1S,6R,7S)-9-Benzyl-9-aza-bicyclo[4.2.1]non-7-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone (446873-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetonitrile

2: AgF / CH₂Cl₂ / 6 h

With silver fluoride; potassium carbonate; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4020(02)00322-8

Reference yield:

N-Boc-perhydroazepine (123387-52-0) → ((1S,6R,7S)-9-Benzyl-9-aza-bicyclo[4.2.1]non-7-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone (446873-03-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / TMEDA; s-BuLi / -78 °C

2: 62 percent / TMEDA; s-BuLi / 5 h / -40 °C

3: 100 percent / TFA / CH₂Cl₂

4: K₂CO₃ / acetonitrile

5: AgF / CH₂Cl₂ / 6 h

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; silver fluoride; potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4020(02)00322-8

upstream raw materials:

acrylcamphorsultam

1-benzyl-2,7-bis-trimethylsilanyl-azepane

hexamethylene imine

benzyl bromide

Downstream raw materials:

(1S,6R,7S)-9-Benzyl-9-aza-bicyclo[4.2.1]nonane-7-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 446873-03-6 ((1S,6R,7S)-9-Benzyl-9-aza-bicyclo[4.2.1]non-7-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

Send

Send

Metric Ton KG G Pound L ML

Send

Send