(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)methanone

Base Information

Chemical Name:(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)methanone
CAS No.:1289562-46-4
Molecular Formula:C₂₄H₁₉N₃O₃
Molecular Weight:397.433
Hs Code.:

Synonyms:

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Chemical Property of (6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)methanone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)methanone

There total 18 articles about (6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1289561-18-7
(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)methanone

: 1289562-48-6
(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)methanone

: 1289562-46-4
(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)methanone

Guidance literature:: With Daicel ChiraCel OD; In ethanol; hexane; Resolution of racemate;
DOI:10.1021/jm101597x

Reference yield:

: 65844-44-2
methyl 6-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

: 1289562-48-6
(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)methanone

: 1289562-46-4
(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)methanone

Guidance literature:: Multi-step reaction with 12 steps

1.1: copper diacetate / dichloromethane / 0.25 h / 20 °C / Molecular sieve

1.2: 17 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

4.1: tetrahydrofuran; water / 16 h / 20 °C

5.1: hydrogenchloride / ethyl acetate / 16 h / Reflux; Inert atmosphere

6.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

9.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 16 h / 20 °C

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

11.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

12.1: Daicel ChiraCel OD / ethanol; hexane / Resolution of racemate

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; water; copper diacetate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; p-toluenesulfonyl chloride; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm101597x

Reference yield:

: 1452-63-7
picolinic acid hydrazide

: 1289562-48-6
(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)methanone

: 1289562-46-4
(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

2: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 16 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

5: Daicel ChiraCel OD / ethanol; hexane / Resolution of racemate

With tetrabutyl ammonium fluoride; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1021/jm101597x