trans-2-(3-Methoxyphenyl)cyclopropanecarboxylic Acid

Base Information

• Chemical Name: trans-2-(3-Methoxyphenyl)cyclopropanecarboxylic Acid
• CAS No.: 34919-31-8
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.214
• European Community (EC) Number: 817-860-5
• DSSTox Substance ID: DTXSID801192250
• Mol file: 34919-31-8.mol

Synonyms:34919-31-8;110901-90-1;(1R,2R)-2-(3-methoxyphenyl)cyclopropane-1-carboxylic acid;trans-2-(3-Methoxyphenyl)cyclopropanecarboxylic Acid;Rel-(1R,2R)-2-(3-methoxyphenyl)cyclopropane-1-carboxylic acid;rac-(1R,2R)-2-(3-methoxyphenyl)cyclopropane-1-carboxylic acid, trans;(1R,2R)-2-(3-Methoxyphenyl)cyclopropanecarboxylic Acid;starbld0015021;SCHEMBL7003208;DTXSID801192250;AC8049;AC9628;AKOS034813951;EN300-250469;Z2242045603;rel-(1R,2R)-2-(3-Methoxyphenyl)cyclopropanecarboxylic acid;rac-(1R,2R)-2-(3-methoxyphenyl)cyclopropane-1-carboxylic acid

Chemical Property of trans-2-(3-Methoxyphenyl)cyclopropanecarboxylic Acid

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 192.078644241
• Heavy Atom Count: 14
• Complexity: 227

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)C2CC2C(=O)O
• Isomeric SMILES: COC1=CC=CC(=C1)[C@@H]2C[C@H]2C(=O)O

Technology Process of trans-2-(3-Methoxyphenyl)cyclopropanecarboxylic Acid

There total 55 articles about trans-2-(3-Methoxyphenyl)cyclopropanecarboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(1R*,2R*)-ethyl 2-(3-methoxyphenyl)cyclopropanecarboxylate (71778-34-2,71778-35-3) → trans-[2-(3-methoxyphenyl)cyclopropane]carboxylic acid (96728-38-0,34919-31-8)

Guidance literature:

(1R*,2R*)-ethyl 2-(3-methoxyphenyl)cyclopropanecarboxylate; With sodium hydroxide; In ethanol; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; at 0 ℃; Inert atmosphere;

DOI:10.1039/c5ob02577j

Reference yield: 97.0%

(1R,2S)-N-<(R)-2-hydroxy-1-phenylethyl>-2-(3-methoxyphenyl)cyclopropanecarboxamide (110826-32-9) → (1R,2S)-2-(3-methoxyphenyl)cyclopropane-1-carboxylic acid (110901-90-1,34919-31-8)

Guidance literature:

With sulfuric acid; In 1,4-dioxane; at 100 ℃; for 24h;

DOI:10.1021/jm00396a014

Reference yield: 97.0%

N-methoxy-N-methyl-trans-2-(3-methoxyphenyl)cyclopropanecarboxamide → trans-[2-(3-methoxyphenyl)cyclopropane]carboxylic acid (96728-38-0,34919-31-8)

Guidance literature:

With potassium tert-butylate; In diethyl ether; at 20 ℃; for 16h;

DOI:10.1139/cjc-77-5-6-1123

upstream raw materials:

trans-1-(m-methoxyphenyl)-2-(β-bromopropionyl)cyclopropane

trans-1-(m-methoxyphenyl)-2-(α,β-dihydroxypropionyl)cyclopropane

trans-3-methoxycinnamic acid

trans-3-(3-methoxyphenyl)acrylic acid methyl ester

Downstream raw materials:

(1R,2S)-2-(3-Methoxy-phenyl)-cyclopropylamine

(1S,2R)-2-(3-Methoxy-phenyl)-cyclopropylamine

(1S,2S)-2-(3-Methoxy-phenyl)-cyclopropylamine