Amg-009

Base Information

• Chemical Name: Amg-009
• CAS No.: 1027847-67-1
• Molecular Formula: C₂₆H₂₆Cl₂N₂O₇S
• Molecular Weight: 581.474
• UNII: 83262TRK3S
• Wikidata: Q27269380
• Pharos Ligand ID: WYXWFRT4BKFL
• ChEMBL ID: CHEMBL589973
• Mol file: 1027847-67-1.mol

Synonyms:AMG 009

Chemical Property of Amg-009

Chemical Property:

• Melting Point: 148.6 °C
• Density: 1.403±0.06 g/cm3(Predicted)
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 12
• Exact Mass: 580.0837777
• Heavy Atom Count: 38
• Complexity: 887

Purity/Quality:

99.90% ^*data from raw suppliers

4-[4-[(Butylamino)carbonyl]-2-[[(2,4-dichlorophenyl)sulfonyl]amino]phenoxy]-3-methoxy-benzeneaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCCCNC(=O)C1=CC(=C(C=C1)OC2=C(C=C(C=C2)CC(=O)O)OC)NS(=O)(=O)C3=C(C=C(C=C3)Cl)Cl

Technology Process of Amg-009

There total 4 articles about Amg-009 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H24N2O5 (1201900-96-0) → AMG009 (1027847-67-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 5 h / 60 °C

2: 2,6-dimethylpyridine / tetrahydrofuran / 12 h / 60 °C

3: water; sodium hydroxide / 2 h / 20 °C

With 2,6-dimethylpyridine; sulfuric acid; water; sodium hydroxide; In tetrahydrofuran;

DOI:10.1021/ml1002234

Reference yield:

C27H28Cl2N2O7S → AMG009 (1027847-67-1)

Guidance literature:

With water; sodium hydroxide; at 20 ℃; for 2h;

DOI:10.1021/ml1002234

Reference yield:

C20H24N2O5 (1201900-96-0) + 2,4-Dichlorobenzenesulfonyl chloride (16271-33-3) → AMG009 (1027847-67-1)

Guidance literature:

With pyridine; at 20 ℃; for 24h;

DOI:10.1016/j.bmcl.2009.09.052

upstream raw materials:

C₂₀H₂₄N₂O₅

2,4-Dichlorobenzenesulfonyl chloride

C₂₁H₂₆N₂O₅