Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4S,5R)-3,4-dihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

Base Information

Chemical Name:Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4S,5R)-3,4-dihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester
CAS No.:208391-08-6
Molecular Formula:C₃₈H₄₁N₇O₁₀
Molecular Weight:755.784
Hs Code.:

Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4S,5R)-3,4-dihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

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Chemical Property of Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4S,5R)-3,4-dihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

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Technology Process of Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4S,5R)-3,4-dihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

There total 3 articles about Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4S,5R)-3,4-dihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 208391-07-5
Dimethyl-carbamic acid 2-acetylamino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

: 14470-28-1
mono-4-methoxytrityl chloride

: 208391-08-6
Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4S,5R)-3,4-dihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

Guidance literature:: With pyridine; triethylamine;
DOI:10.1016/S0960-894X(98)00150-4

Reference yield:

: 29851-56-7
8-oxo-7,8-dihydro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-N²-acetylguanine

: 208391-08-6
Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4S,5R)-3,4-dihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: EtN(i-Pr)2, pyridine / 5 h / Ambient temperature

2: t-BuOK / methanol / 0.5 h

3: 72 percent / Et₃N, pyridine

With pyridine; potassium tert-butylate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol;
DOI:10.1016/S0960-894X(98)00150-4

Reference yield:

: Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(2-acetylamino-7-dimethylcarbamoyl-6-dimethylcarbamoyloxy-8-oxo-7,8-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

: 208391-08-6
Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4S,5R)-3,4-dihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: t-BuOK / methanol / 0.5 h

2: 72 percent / Et₃N, pyridine

With pyridine; potassium tert-butylate; triethylamine; In methanol;
DOI:10.1016/S0960-894X(98)00150-4