Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

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Chemical Name:Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester
CAS No.:208391-09-7
Molecular Formula:C₄₄H₅₅N₇O₁₀Si
Molecular Weight:870.047
Hs Code.:

Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

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Chemical Property of Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

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Technology Process of Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

There total 4 articles about Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 208391-08-6
Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4S,5R)-3,4-dihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

: 208391-09-7
Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

Guidance literature:: for 6h; Ambient temperature;
DOI:10.1016/S0960-894X(98)00150-4

Reference yield:

: 29851-56-7
8-oxo-7,8-dihydro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-N²-acetylguanine

: 208391-09-7
Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: EtN(i-Pr)2, pyridine / 5 h / Ambient temperature

2: t-BuOK / methanol / 0.5 h

3: 72 percent / Et₃N, pyridine

4: 53 percent / 6 h / Ambient temperature

With pyridine; potassium tert-butylate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol;
DOI:10.1016/S0960-894X(98)00150-4

Reference yield:

: Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(2-acetylamino-7-dimethylcarbamoyl-6-dimethylcarbamoyloxy-8-oxo-7,8-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

: 208391-09-7
Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: t-BuOK / methanol / 0.5 h

2: 72 percent / Et₃N, pyridine

3: 53 percent / 6 h / Ambient temperature

With pyridine; potassium tert-butylate; triethylamine; In methanol;
DOI:10.1016/S0960-894X(98)00150-4