Philanthotoxin 74

Base Information

• Chemical Name: Philanthotoxin 74
• CAS No.: 1227301-51-0
• Molecular Formula: C₂₄H₄₂N₄O₃*2ClH
• Molecular Weight: 507.544
• Mol file: 1227301-51-0.mol

Synonyms:

Chemical Property of Philanthotoxin 74

Chemical Property:

• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

Philanthotoxin74(hydrochloride) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Philanthotoxin 74 is an AMPA receptor antagonist.

Technology Process of Philanthotoxin 74

There total 7 articles about Philanthotoxin 74 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[2-(4-benzyloxy-phenyl)-1-(7-hydroxy-heptylcarbamoyl)-ethyl]-butyramide (937377-31-6) → N-[1-[7-(4-amino-butylamino)-heptylcarbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-butyramide dihydrochloride (1227301-51-0)

Guidance literature:

Multi-step reaction with 4 steps

1: diisopropylethylamine / CH₂Cl₂ / 4 h

2: 5.82 g / diisopropylethylamine / acetonitrile / 48 h / 35 °C

3: H₂ / palladium hydroxide / methanol / 16 h / 20 °C / 760.05 Torr

4: HCl / methanol / 3 h / 20 °C

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/ja0705801

Reference yield:

C28H40N2O6S → N-[1-[7-(4-amino-butylamino)-heptylcarbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-butyramide dihydrochloride (1227301-51-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 5.82 g / diisopropylethylamine / acetonitrile / 48 h / 35 °C

2: H₂ / palladium hydroxide / methanol / 16 h / 20 °C / 760.05 Torr

3: HCl / methanol / 3 h / 20 °C

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In methanol; acetonitrile;

DOI:10.1021/ja0705801

Reference yield:

(4-{7-[3-(4-benzyloxy-phenyl)-2-butyrylamino-propionylamino]-heptylamino}-butyl)-carbamic acid tert-butyl ester (937377-32-7) → N-[1-[7-(4-amino-butylamino)-heptylcarbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-butyramide dihydrochloride (1227301-51-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / palladium hydroxide / methanol / 16 h / 20 °C / 760.05 Torr

2: HCl / methanol / 3 h / 20 °C

With hydrogenchloride; hydrogen; palladium dihydroxide; In methanol;

DOI:10.1021/ja0705801

upstream raw materials:

N-[2-(4-benzyloxy-phenyl)-1-(7-hydroxy-heptylcarbamoyl)-ethyl]-butyramide

(4-{7-[3-(4-benzyloxy-phenyl)-2-butyrylamino-propionylamino]-heptylamino}-butyl)-carbamic acid tert-butyl ester

7-bromoheptyl alcohol

7-azido-heptan-1-ol

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