N-[2-(4-benzyloxy-phenyl)-1-(7-hydroxy-heptylcarbamoyl)-ethyl]-butyramide

Base Information

• Chemical Name: N-[2-(4-benzyloxy-phenyl)-1-(7-hydroxy-heptylcarbamoyl)-ethyl]-butyramide
• CAS No.: 937377-31-6
• Molecular Formula: C₂₇H₃₈N₂O₄
• Molecular Weight: 454.61
• Mol file: 937377-31-6.mol

Synonyms:N-[2-(4-benzyloxy-phenyl)-1-(7-hydroxy-heptylcarbamoyl)-ethyl]-butyramide

Chemical Property of N-[2-(4-benzyloxy-phenyl)-1-(7-hydroxy-heptylcarbamoyl)-ethyl]-butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(4-benzyloxy-phenyl)-1-(7-hydroxy-heptylcarbamoyl)-ethyl]-butyramide

There total 6 articles about N-[2-(4-benzyloxy-phenyl)-1-(7-hydroxy-heptylcarbamoyl)-ethyl]-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

7-amino-1-heptanol (19243-04-0) + 3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid 4-nitro-phenyl ester (125376-03-6) → N-[2-(4-benzyloxy-phenyl)-1-(7-hydroxy-heptylcarbamoyl)-ethyl]-butyramide (937377-31-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/ja0705801

Reference yield:

7-bromoheptyl alcohol (10160-24-4) → N-[2-(4-benzyloxy-phenyl)-1-(7-hydroxy-heptylcarbamoyl)-ethyl]-butyramide (937377-31-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / NaN₃; n-Bu₄NBr / benzene / 16 h / Heating

2: 80 percent / H₂ / Pd / methanol / 16 h / 20 °C / 760.05 Torr

3: 99 percent / tetrahydrofuran / 16 h / 20 °C

With sodium azide; tetrabutylammomium bromide; hydrogen; palladium; In tetrahydrofuran; methanol; benzene;

DOI:10.1021/ja0705801

Reference yield:

7-azido-heptan-1-ol (57395-45-6) → N-[2-(4-benzyloxy-phenyl)-1-(7-hydroxy-heptylcarbamoyl)-ethyl]-butyramide (937377-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / H₂ / Pd / methanol / 16 h / 20 °C / 760.05 Torr

2: 99 percent / tetrahydrofuran / 16 h / 20 °C

With hydrogen; palladium; In tetrahydrofuran; methanol;

DOI:10.1021/ja0705801

upstream raw materials:

7-amino-1-heptanol

3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid 4-nitro-phenyl ester

7-bromoheptyl alcohol

7-azido-heptan-1-ol

Downstream raw materials:

N-[1-[7-(4-amino-butylamino)-heptylcarbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-butyramide dihydrochloride

(4-{7-[2-butyrylamino-3-(4-hydroxy-phenyl)-propionylamino]-heptylamino}-butyl)-carbamic acid tert-butyl ester

(4-{7-[3-(4-benzyloxy-phenyl)-2-butyrylamino-propionylamino]-heptylamino}-butyl)-carbamic acid tert-butyl ester