Diethyl {[(4-methylpyridin-2-yl)amino]methylidene}propanedioate

Base Information

Chemical Name:Diethyl {[(4-methylpyridin-2-yl)amino]methylidene}propanedioate
CAS No.:19056-88-3
Molecular Formula:C₁₄H₁₈N₂O₄
Molecular Weight:278.308
Hs Code.:2933399090
NSC Number:159400
DSSTox Substance ID:DTXSID60303620
ChEMBL ID:CHEMBL3209037
Mol file:19056-88-3.mol

Synonyms:19056-88-3;((4-METHYL-2-PYRIDYLAMINO)METHYLIDENE)MALONIC ACID DIETHYL ESTER;diethyl {[(4-methylpyridin-2-yl)amino]methylidene}propanedioate;diethyl 2-[[(4-methylpyridin-2-yl)amino]methylidene]propanedioate;SR-01000312068;NSC159400;BTCPHCL;CBDivE_006580;MLS000562368;CHEMBL3209037;DTXSID60303620;HMS2580G04;2-[(4-Methyl-pyridin-2-ylamino)-methylene]-malonic acid diethyl ester;STK022430;AKOS000613280;NSC-159400;SMR000175036;FT-0604365;SR-01000312068-1;SR-01000312068-2;diethyl 2-((4-methylpyridin-2-ylamino)methylene)malonate;((4-Methyl-2-pyridylamino)methylidene)malonicaciddiethylester;DIETHYL 2-{[(4-METHYL-2-PYRIDYL)AMINO]METHYLENE}MALONATE

Suppliers and Price of Diethyl {[(4-methylpyridin-2-yl)amino]methylidene}propanedioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
((4-METHYL-2-PYRIDYLAMINO)METHYLIDENE)MALONIC ACID DIETHYL ESTER 95.00%
5MG
$ 495.00

Total 3 raw suppliers

Chemical Property of Diethyl {[(4-methylpyridin-2-yl)amino]methylidene}propanedioate

Chemical Property:

Vapor Pressure:1.22E-05mmHg at 25°C
Boiling Point:369.1°Cat760mmHg
Flash Point:177°C
PSA：77.52000
Density:1.187g/cm³
LogP:1.88500
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:278.12665706
Heavy Atom Count:20
Complexity:348

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

((4-METHYL-2-PYRIDYLAMINO)METHYLIDENE)MALONIC ACID DIETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(=CNC1=NC=CC(=C1)C)C(=O)OCC

Technology Process of Diethyl {[(4-methylpyridin-2-yl)amino]methylidene}propanedioate

There total 1 articles about Diethyl {[(4-methylpyridin-2-yl)amino]methylidene}propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 695-34-1
2-Amino-4-methylpyridine

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 19056-88-3
diethyl(4-methyl-2-pyridylamino)methylenemalonate

Guidance literature:: for 0.00833333h; Microwave irradiation;
DOI:10.1080/00397911.2010.486515

Reference yield: 88.4%

: 19056-88-3
diethyl(4-methyl-2-pyridylamino)methylenemalonate

: 34667-64-6
3-ethoxycarbonyl-8-methyl-4-oxo-4H-pyrido<1,2-a>pyrimidine

Guidance literature:: In diphenylether; for 8h; Reflux;
DOI:10.1016/j.bmc.2012.09.008

Reference yield:

: 19056-88-3
diethyl(4-methyl-2-pyridylamino)methylenemalonate

: 34662-59-4
8-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: diphenylether / 8 h / Reflux

2: hydrogenchloride / 2 h / Reflux

With hydrogenchloride; In diphenylether;
DOI:10.1016/j.bmc.2012.09.008