34667-64-6Relevant academic research and scientific papers
Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors
Mane,Li,Huang,Gupta,Nadkarni,Giridhar,Naik,Yadav
, p. 6296 - 6304 (2012/11/13)
Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is a promising target for antimalarial chemotherapy and inhibition of this protease affects the growth of parasite adversely. A series of pyrido[1,2-a]pyrimidin-4-ones were synthesized and evaluat
Limitations of the Jacobs-Gould reaction using microwave irradiation
Smith, Robert B.,Faki, Hajira,Leslie, Ray
experimental part, p. 1492 - 1499 (2011/06/17)
Upon investigating the green synthesis of some antimicrobial quinolone compounds, some atypical ring-closing patterns were observed during the synthesis of various intermediates using the Jacobs-Gould reaction.
Diethyl N,N-dimethylaminomethylenemalonate in the synthesis of fused heterocyclic systems
Kusar, Mihael,Svete, Jurij,Stanovnik, Branko
, p. 1041 - 1046 (2007/10/03)
The reactions of diethyl N,N-dimethylaminomethylenemalonate (3) with N- and C- nucleophiles were studied. In the reaction of 3 with heterocyclic amines 4, with the amino group attached at α-position in respect to the ring nitrogen atom, substitution of th
