8-benzyloxy-6,7-bis-(tert-butyl-dimethyl-silanyloxy)-1-{10-[2-(4-methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-octan-2-one

Base Information

Chemical Name:8-benzyloxy-6,7-bis-(tert-butyl-dimethyl-silanyloxy)-1-{10-[2-(4-methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-octan-2-one
CAS No.:236427-86-4
Molecular Formula:C₆₃H₁₁₂O₁₂Si₄
Molecular Weight:1173.92
Hs Code.:

8-benzyloxy-6,7-bis-(<i>tert</i>-butyl-dimethyl-silanyloxy)-1-{10-[2-(4-methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-octan-2-one

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Chemical Property of 8-benzyloxy-6,7-bis-(tert-butyl-dimethyl-silanyloxy)-1-{10-[2-(4-methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-octan-2-one

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Technology Process of 8-benzyloxy-6,7-bis-(tert-butyl-dimethyl-silanyloxy)-1-{10-[2-(4-methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-octan-2-one

There total 26 articles about 8-benzyloxy-6,7-bis-(tert-butyl-dimethyl-silanyloxy)-1-{10-[2-(4-methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-octan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 236427-86-4
8-benzyloxy-6,7-bis-(tert-butyl-dimethyl-silanyloxy)-1-{10-[2-(4-methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-octan-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

2: 81 percent / H₂ / Raney Ni (W₂) / ethanol / 4 h / Ambient temperature

3: 100 percent / Dess-Martin periodinane / CH₂Cl₂ / 5 h / Ambient temperature

4: 1.) BuLi / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 1.5 h

5: Dess-Martin periodinane / CH₂Cl₂ / 3 h / Ambient temperature

6: SmI₂ / tetrahydrofuran; methanol / 1 h / -95 - -80 °C

7: Zn-Cu couple, NH₄Cl / methanol / 0.17 h / Ambient temperature

With 2,6-dimethylpyridine; n-butyllithium; samarium diiodide; hydrogen; copper; ammonium chloride; Dess-Martin periodane; zinc; Raney Ni (W₂); In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1055/s-1999-2689

Reference yield:

: (2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecan-5-ol

: 236427-86-4
8-benzyloxy-6,7-bis-(tert-butyl-dimethyl-silanyloxy)-1-{10-[2-(4-methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-octan-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

2: 81 percent / H₂ / Raney Ni (W₂) / ethanol / 4 h / Ambient temperature

3: 100 percent / Dess-Martin periodinane / CH₂Cl₂ / 5 h / Ambient temperature

4: 1.) BuLi / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 1.5 h

5: Dess-Martin periodinane / CH₂Cl₂ / 3 h / Ambient temperature

6: SmI₂ / tetrahydrofuran; methanol / 1 h / -95 - -80 °C

7: Zn-Cu couple, NH₄Cl / methanol / 0.17 h / Ambient temperature

With 2,6-dimethylpyridine; n-butyllithium; samarium diiodide; hydrogen; copper; ammonium chloride; Dess-Martin periodane; zinc; Raney Ni (W₂); In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1055/s-1999-2689

Reference yield:

: 236427-81-9
{(2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-5-yloxy}-triethyl-silane

: 236427-86-4
8-benzyloxy-6,7-bis-(tert-butyl-dimethyl-silanyloxy)-1-{10-[2-(4-methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-octan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / H₂ / Raney Ni (W₂) / ethanol / 4 h / Ambient temperature

2: 100 percent / Dess-Martin periodinane / CH₂Cl₂ / 5 h / Ambient temperature

3: 1.) BuLi / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 1.5 h

4: Dess-Martin periodinane / CH₂Cl₂ / 3 h / Ambient temperature

5: SmI₂ / tetrahydrofuran; methanol / 1 h / -95 - -80 °C

6: Zn-Cu couple, NH₄Cl / methanol / 0.17 h / Ambient temperature

With n-butyllithium; samarium diiodide; hydrogen; copper; ammonium chloride; Dess-Martin periodane; zinc; Raney Ni (W₂); In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1055/s-1999-2689