C₂₈H₂₇F₂N₃O₃

Base Information

Chemical Name:C₂₈H₂₇F₂N₃O₃
CAS No.:1417404-26-2
Molecular Formula:C₂₈H₂₇F₂N₃O₃
Molecular Weight:491.537
Hs Code.:

C<sub>28</sub>H<sub>27</sub>F<sub>2</sub>N<sub>3</sub>O<sub>3</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₈H₂₇F₂N₃O₃

Chemical Property:

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Technology Process of C₂₈H₂₇F₂N₃O₃

There total 12 articles about C₂₈H₂₇F₂N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1417403-99-6
8-chloro-5-oxo-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-3-carboxylic acid 2-(morpholin-4-yl)ethyl amide

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 1417404-26-2
C₂₈H₂₇F₂N₃O₃

Guidance literature:: With potassium tert-butylate; palladium diacetate; XPhos; In toluene; tert-butyl alcohol; for 2h; Inert atmosphere; Reflux;
DOI:10.1021/jm301539x

Reference yield:

: C₁₆H₁₂Cl₂O₃

: 1417404-26-2
C₂₈H₂₇F₂N₃O₃

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 °C

2: tetrahydrofuran / 1.5 h / 20 °C

3: tetrahydrofuran

4: palladium diacetate; XPhos; potassium tert-butylate / toluene; tert-butyl alcohol / 2 h / Inert atmosphere; Reflux

With aluminum (III) chloride; potassium tert-butylate; palladium diacetate; XPhos; In tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol; 1: |Friedel-Crafts Acylation / 4: |Buchwald-Hartwig Coupling;
DOI:10.1021/jm301539x

Reference yield:

: 1943-88-0
2,4-dicyanotoluene

: 1417404-26-2
C₂₈H₂₇F₂N₃O₃

Guidance literature:: Multi-step reaction with 9 steps

1.1: water; sodium hydroxide / diethylene glycol / 120 h / Reflux

2.1: sulfuric acid / 6 h / Reflux

3.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 1 h / -78 - 0 °C

3.2: -78 - 0 °C

4.1: potassium hydroxide / methanol / 6 h / Reflux

5.1: thionyl chloride / dichloromethane / Reflux

6.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 °C

7.1: tetrahydrofuran / 1.5 h / 20 °C

8.1: tetrahydrofuran

9.1: palladium diacetate; XPhos; potassium tert-butylate / toluene; tert-butyl alcohol / 2 h / Inert atmosphere; Reflux

With aluminum (III) chloride; n-butyllithium; thionyl chloride; sulfuric acid; potassium tert-butylate; water; palladium diacetate; diisopropylamine; potassium hydroxide; sodium hydroxide; XPhos; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene; tert-butyl alcohol; diethylene glycol; 6.1: |Friedel-Crafts Acylation / 9.1: |Buchwald-Hartwig Coupling;
DOI:10.1021/jm301539x