1943-88-0

Basic information

• Product Name: 4-METHYL-ISOPHTHALONITRILE
• Synonyms: 4-METHYL-ISOPHTHALONITRILE
• CAS NO: 1943-88-0
• Molecular Formula: C₉H₆N₂
• Molecular Weight: 142.16
• Mol File: 1943-88-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-METHYL-ISOPHTHALONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-ISOPHTHALONITRILE(1943-88-0)
• EPA Substance Registry System: 4-METHYL-ISOPHTHALONITRILE(1943-88-0)

Safety Data

• Hazardous Substances Data: 1943-88-0(Hazardous Substances Data)

Usage

General Description

4-Methyl-isophthalonitrile is a chemical compound with the formula C9H7N. It is a light yellow crystalline solid with a molecular weight of 129.16 g/mol. 4-METHYL-ISOPHTHALONITRILE is commonly used in the production of dyes, pigments, and polymers. It is also utilized as a raw material in the synthesis of various pharmaceuticals and agricultural chemicals. Due to its aromatic structure, 4-methyl-isophthalonitrile is a versatile building block in organic synthesis, and its derivatives have a wide range of industrial applications. It is important to handle this chemical with care, as it may be harmful if ingested or inhaled, and can cause skin and eye irritation upon contact.

Upstream product

• 31543-75-6 2,4-dibromotoluene 
• 7717-24-0 2-pentenedinitrile 
• 78-94-4 methyl vinyl ketone 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 135579-87-2 4-cyano-benzylzinc bromide 
• 626-17-5 benzene-1,3-dicarbonitrile 
• 124-40-3 dimethyl amine 
• 91-20-3 naphthalene 
• 93-04-9 2-Methoxynaphthalene 
• 95-73-8 2,4-dichlorotoluene 
• 544-92-3 copper(I) cyanide 
• 85-01-8 phenanthrene 
• 121-45-9 phosphorous acid trimethyl ester 
• 109-89-7 diethylamine 

Downstream Products

• 3347-99-7 4-methyl isophthalic acid 
• 102028-97-7 4'-dimethylamino-trans-stilbene-2,4-dicarbonitrile 
• 50670-74-1 4-bromomethylisophthalonitrile 
• 23038-61-1 dimethyl 4-methylbenzene-1,3-dicarboxylate 
• 1417404-25-1 C₂₆H₂₂F₂N₂O₃ 
• 1417403-96-3 4-[2-(3-chlorophenyl)ethyl]isophthalic acid dimethyl ester 
• 1417404-26-2 C₂₈H₂₇F₂N₃O₃ 
• 1417404-27-3 8-((3-benzamido-4-fluorophenyl)amino)-N-(2-morpholinoethyl)-5-oxo-10,11-dihydro-5H-dibenzo[a,d][7]annulene-3-carboxamide 
• 1417404-28-4 8-((2,4-difluorophenyl)amino)-5-oxo-10,11-dihydro-5H-dibenzo[a,d][7]annulene-3-carboxylic acid 
• 1417404-29-5 C₂₂H₁₆F₂N₂O₂ 
• 1417404-30-8 C₂₃H₁₈F₂N₂O₂ 
• 1417404-31-9 C₃₀H₃₀F₂N₂O₂ 
• 1417404-32-0 C₂₄H₁₉F₃N₂O₂ 
• 1417404-33-1 C₂₄H₁₉ClF₂N₂O₂ 

Relevant articles and documents

Preparation of polyfunctional nitriles by the cyanation of functionalized organozinc halides with p-toluenesulfonyl cyanide

Various alkyl, alkenyl, akynyl, benzylic, aromatic or heterocyclic organozinc halides bearing functional groups such as an ester, a boronic ester, a cyanide, a halide or a trialkoxysilyl group react under mild conditions with p-toluenesulfonyl cyanide affording polyfunctional nitriles in 69-93% yields.

A novel and convenient synthesis of benzonitriles: Electrophilic cyanation of aryl and heteroaryl bromides

N-Cyano-N-phenyl-p-methylbenzenesulfonamide has been used as a more benign electrophilic cyanation reagent for the synthesis of various benzonitriles from (hetero)aryl bromides via formation of Grignard reagents. Electronically different and sterically demanding aryl bromides including functionalized substrates and heteroaryl bromides are successfully cyanated in good to excellent yields. The efficiency of the present methodology is shown by the expeditious syntheses of interesting pharmaceutical intermediates. Notably, chemoselective monocyanation of dibromoarenes is also achieved. Copyright

DIPEPTIDYL PEPTIDASE-IV INHIBITORS

The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.