5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-(3,7,14-trioxo-5,16-dioxa-2,8,13-triazaoctadecan-18-oyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-(3,7,14-trioxo-5,16-dioxa-2,8,13-triazaoctadecan-18-oyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide
CAS No.:1443990-82-6
Molecular Formula:C₃₅H₄₂Cl₃N₇O₇
Molecular Weight:779.12
Hs Code.:

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-(3,7,14-trioxo-5,16-dioxa-2,8,13-triazaoctadecan-18-oyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide

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Chemical Property of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-(3,7,14-trioxo-5,16-dioxa-2,8,13-triazaoctadecan-18-oyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide

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Technology Process of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-(3,7,14-trioxo-5,16-dioxa-2,8,13-triazaoctadecan-18-oyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide

There total 4 articles about 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-(3,7,14-trioxo-5,16-dioxa-2,8,13-triazaoctadecan-18-oyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1443990-83-7
C₉H₁₉N₃O₃

: 1443990-85-9
2-(2-(4-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamido)piperidin-1-yl)-2-oxoethoxy)acetic acid

: 1443990-82-6
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-(3,7,14-trioxo-5,16-dioxa-2,8,13-triazaoctadecan-18-oyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: 2-(2-(4-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamido)piperidin-1-yl)-2-oxoethoxy)acetic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h; Inert atmosphere;

C₉H₁₉N₃O₃; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm4005219

Reference yield:

: 162758-35-2
rimonabant acid

: 1443990-82-6
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-(3,7,14-trioxo-5,16-dioxa-2,8,13-triazaoctadecan-18-oyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / toluene / 3 h / Reflux

2.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

4.1: pyridine / dichloromethane / 20 °C

5.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

5.2: 0 - 20 °C / Inert atmosphere

With pyridine; thionyl chloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm4005219

Reference yield:

: 1365037-83-7
tert-butyl 4-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate

: 1443990-82-6
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-(3,7,14-trioxo-5,16-dioxa-2,8,13-triazaoctadecan-18-oyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

2.1: pyridine / dichloromethane / 20 °C

3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With pyridine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm4005219