(R)-Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(2-nitro-benzyl) ester O'-(4-nitro-phenyl) ester

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Chemical Name:(R)-Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(2-nitro-benzyl) ester O'-(4-nitro-phenyl) ester
CAS No.:126354-80-1
Molecular Formula:C₄₃H₃₉N₄O₁₂PS
Molecular Weight:866.842
Hs Code.:

(R)-Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(2-nitro-benzyl) ester O'-(4-nitro-phenyl) ester

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Chemical Property of (R)-Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(2-nitro-benzyl) ester O'-(4-nitro-phenyl) ester

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Technology Process of (R)-Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(2-nitro-benzyl) ester O'-(4-nitro-phenyl) ester

There total 8 articles about (R)-Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(2-nitro-benzyl) ester O'-(4-nitro-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: C₃₆H₃₃N₃O₁₀PS^(1-)*Na⁽¹⁺⁾

: 3958-60-9
2-nitrophenylmethyl bromide

: 126354-79-8,126354-80-1
5'-O-monomethoxytritylthymidine 3'-O-

Guidance literature:: In acetone;
DOI:10.1016/S0040-4039(01)80667-5

Reference yield:

: 75414-48-1
5'-O-monomethoxytritylthymidine 3'-O-(4-nitrophenyl) phosphoranilidate

: 126354-79-8,126354-80-1
5'-O-monomethoxytritylthymidine 3'-O-

Guidance literature:: Multi-step reaction with 2 steps

1: NaH, CS₂ / dioxane

2: 80 percent / acetone

With carbon disulfide; sodium hydride; In 1,4-dioxane; acetone;
DOI:10.1016/S0040-4039(01)80667-5

Reference yield:

: 75414-48-1
5'-O-monomethoxytritylthymidine 3'-O-(4-nitrophenyl) phosphoranilidate

: 126354-80-1
(R)-Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(2-nitro-benzyl) ester O'-(4-nitro-phenyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaH, CS₂ / dioxane

2: acetone

With carbon disulfide; sodium hydride; In 1,4-dioxane; acetone;
DOI:10.1016/S0040-4039(01)80667-5