75414-48-1

Upstream product

• 75414-47-0 O-(4-nitrophenyl)-N-phenylphosphoramidochloridate 
• 124680-51-9 (2R,4R,5R)-1-[5-[bis(4-methoxyphenyl)phenylmethoxymethyl]-4-hydroxytetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 42926-80-7 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine 
• 777-52-6 1-dichlorophosphoryloxy-4-nitro-benzene 
• 62-53-3 aniline 

Downstream Products

• 126354-81-2 C₄₉H₅₀N₅O₁₅PS 
• 126354-81-2 C₄₉H₅₀N₅O₁₅PS 
• 126354-80-1 (R)-Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(2-nitro-benzyl) ester O'-(4-nitro-phenyl) ester 
• 126354-79-8 (S)-Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(2-nitro-benzyl) ester O'-(4-nitro-phenyl) ester 
• 126354-79-8 5'-O-monomethoxytritylthymidine 3'-O- 
• 16562-50-8 thymidine 3'-O-(4-nitrophenyl)phosphate 

Relevant academic research and scientific papers

STUDIES ON STEREOSPECIFIC FORMATION OF P-CHIRAL INTERNUCLEOTIDE LINKAGE. SYNTHESIS OF (Rp,Rp)- AND (Sp,Sp)-THYMIDYLYL(3',5')THYMIDYLYL(3',5')THYMIDINE DI(O,O-PHOSPHOROTHIOATE) USING 2-NITROBENZYL GROUP AS A NEW S-PROTECTION

(Rp,Rp)- and (Sp,Sp)-diastereomers of thymidylyl(3',5')thymidylyl(3',5')thymidine di (O,O-phosphorothioate (6) were prepared in the stereospecific reaction of (Rp)- or (Sp)-isomer of 5'-O-monomethoxytritylthymidine 3'-O- (2) with 5'-OH activated 3'-O-acetylthymidine and subsequently with 5'-OH deprotected, 5'-OH activated derivative of resulted dinucleotide 3.

2'-DEOXYRIBONUCLEOSIDE 3'-ARYL PHOSPHORANILIDATES KEY INTERMEDIATES IN THE STEREOSPECIFIC SYNTHESIS OF 2'-DEOXYRIBONUCLEOSIDE CYCLIC 3',5'-PHOSPHOROTHIOATES AND DINUCLEOSIDE(3'->5')-PHOSPHOROTHIOATES

Phosphorylation of the 5'-O-monomethoxytrityl-2'-deoxyribonucleosides by means of aryl phosphoranilidochloridates gives the diastereomers of 5'-O-monomethoxytrityl-2'-deoxyribonucleoside 3'-aryl phosphoranilidates.Their separation can be performed by mean

Synthesis of 4-Nitrophenyl Esters of Thymidine 3'-Phosphate and 3'-Phosphorothioate using a New Phosphorylating Agent

2'-Desoxynucleoside-3'-O-(4-nitrophenyl) phosphoranilidates (e.g., 2), prepared by the action of O-(4-nitrophenyl) N-phenylphosphoramidochloridate (1) on alcohols, are converted into the corresponding 4-nitrophenyl phosphate esters (e.g., 3) or P-chiral 4-nitrophenyl phosphorothioate esters (e.g., 4) by treatment with NaH-CX2 (X = O or S).