3-N,3'-O-bis(benzyloxymethyl)-2'-deoxy-5'-O-phpsphonomethyluridine monobenzyl ester

Base Information

Chemical Name:3-N,3'-O-bis(benzyloxymethyl)-2'-deoxy-5'-O-phpsphonomethyluridine monobenzyl ester
CAS No.:132062-85-2
Molecular Formula:C₃₃H₃₇N₂O₁₀P
Molecular Weight:652.638
Hs Code.:

Synonyms:

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Chemical Property of 3-N,3'-O-bis(benzyloxymethyl)-2'-deoxy-5'-O-phpsphonomethyluridine monobenzyl ester

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Technology Process of 3-N,3'-O-bis(benzyloxymethyl)-2'-deoxy-5'-O-phpsphonomethyluridine monobenzyl ester

There total 7 articles about 3-N,3'-O-bis(benzyloxymethyl)-2'-deoxy-5'-O-phpsphonomethyluridine monobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 132062-85-2
3-N,3'-O-bis(benzyloxymethyl)-2'-deoxy-5'-O-phpsphonomethyluridine monobenzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 5 h / 56 °C

2: ethyldiisopropylamine / 1 h / 50 °C

3: sodium methoxide / methanol / 1 h / Ambient temperature

4: 1.) sodium hydride / 1.) DMF, toluene, RT, 30 min, 2.) DMF, toluene, RT, 3 h

With sodium methylate; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; acetone;

Reference yield:

: 17176-77-1
Dibenzyl phosphite

: 132062-85-2
3-N,3'-O-bis(benzyloxymethyl)-2'-deoxy-5'-O-phpsphonomethyluridine monobenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / triethylamine / 0.25 h / 80 °C

2: 55 percent / triethylamine, 4-(dimethylamino)pyridine / acetonitrile / 1 h / 20 °C

3: 1.) sodium hydride / 1.) DMF, toluene, RT, 30 min, 2.) DMF, toluene, RT, 3 h

With dmap; sodium hydride; triethylamine; In acetonitrile;

Reference yield:

: 114790-35-1
dibenzyl hydroxymethylphosphonate

: 132062-85-2
3-N,3'-O-bis(benzyloxymethyl)-2'-deoxy-5'-O-phpsphonomethyluridine monobenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / triethylamine, 4-(dimethylamino)pyridine / acetonitrile / 1 h / 20 °C

2: 1.) sodium hydride / 1.) DMF, toluene, RT, 30 min, 2.) DMF, toluene, RT, 3 h

With dmap; sodium hydride; triethylamine; In acetonitrile;