(4aS,6R,11bS)-5-Benzenesulfonyl-2,2-dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

Base Information

Chemical Name:(4aS,6R,11bS)-5-Benzenesulfonyl-2,2-dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene
CAS No.:123474-72-6
Molecular Formula:C₂₉H₃₁NO₉S
Molecular Weight:569.632
Hs Code.:

(4aS,6R,11bS)-5-Benzenesulfonyl-2,2-dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4aS,6R,11bS)-5-Benzenesulfonyl-2,2-dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

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Technology Process of (4aS,6R,11bS)-5-Benzenesulfonyl-2,2-dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

There total 24 articles about (4aS,6R,11bS)-5-Benzenesulfonyl-2,2-dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 123492-35-3
N-[(R)-[6-((4R,5S)-5-Bromo-2,2-dimethyl-[1,3]dioxan-4-yl)-benzo[1,3]dioxol-5-yl]-(3,4,5-trimethoxy-phenyl)-methyl]-benzenesulfonamide

: 123474-72-6,123537-63-3
(4aR,11bR)-5-Benzenesulfonyl-2,2-dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4039(00)95275-4

Reference yield:

: 58095-76-4
(E)-3-(benzo[d][1,3]dioxol-5-yl)prop-2-en-1-ol

: 123474-72-6,123537-63-3
(4aR,11bR)-5-Benzenesulfonyl-2,2-dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

Guidance literature:: Multi-step reaction with 4 steps

1: aqueous pyridinium bromide / dioxane / 72 h

2: p-toluenesulfonic acid / CH₂Cl₂ / 24 h / 23 °C

3: 1.) BuLi / 1.) THF, -75 deg C, 10 min

4: 78 percent / sodium hydride / dimethylformamide / 0 °C

With n-butyllithium; Pyridine hydrobromide; sodium hydride; toluene-4-sulfonic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)95275-4

Reference yield:

: 58095-76-4
(E)-3-(benzo[d][1,3]dioxol-5-yl)prop-2-en-1-ol

: 123474-72-6,123537-63-3
(4aR,6R,11bR)-5-Benzenesulfonyl-2,2-dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

Guidance literature:: Multi-step reaction with 4 steps

1: aqueous pyridinium bromide / dioxane / 72 h

2: p-toluenesulfonic acid / CH₂Cl₂ / 24 h / 23 °C

3: 1.) BuLi / 1.) THF, -75 deg C, 10 min

4: sodium hydride / dimethylformamide / 0 °C

With n-butyllithium; Pyridine hydrobromide; sodium hydride; toluene-4-sulfonic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)95275-4