C₂₀H₁₉NO₃

Base Information

• Chemical Name: C₂₀H₁₉NO₃
• CAS No.: 1263189-24-7
• Molecular Formula: C₂₀H₁₉NO₃
• Molecular Weight: 321.376
• Mol file: 1263189-24-7.mol

Synonyms:

Chemical Property of C₂₀H₁₉NO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₁₉NO₃

There total 9 articles about C₂₀H₁₉NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H18O4 → C20H19NO3 (1263189-24-7)

Guidance literature:

With ammonia; In methanol; at 60 ℃; for 12h;

DOI:10.1016/j.bmcl.2015.08.077

Reference yield:

1-bromo-2,4-dimethylbenzene (583-70-0) → C20H19NO3 (1263189-24-7)

Guidance literature:

Multi-step reaction with 4 steps

2: thionyl chloride; triethylamine / dichloromethane / 5 h / 40 °C

3: potassium carbonate / acetone / 3 h / 60 °C

4: ammonia / methanol / 12 h / 60 °C

With thionyl chloride; ammonia; potassium carbonate; triethylamine; In methanol; dichloromethane; acetone; 1: |Ullmann Condensation;

DOI:10.1016/j.bmcl.2015.08.077

Reference yield:

C14H19NO2 → C20H19NO3 (1263189-24-7)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium ethanolate / ethanol / 8 h / 80 °C

2: acetic acid / 40 °C

3: sodium tetrahydroborate / methanol / 2 h / 20 °C

4: thionyl chloride; triethylamine / dichloromethane / 5 h / 40 °C

5: potassium carbonate / acetone / 3 h / 60 °C

6: ammonia / methanol / 12 h / 60 °C

With sodium tetrahydroborate; thionyl chloride; ammonia; sodium ethanolate; potassium carbonate; acetic acid; triethylamine; In methanol; ethanol; dichloromethane; acetone;

DOI:10.1016/j.bmcl.2015.08.077

upstream raw materials:

1-bromo-2,4-dimethylbenzene

2,4-Xylenol

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

(2,4-dimethyl-phenoxy)-acetone