5,6,8-Trimethoxy-2-(4-methoxyphenyl)-7-(phenylmethoxy)-4H-1-benzopyran-4-one

Base Information

Chemical Name:5,6,8-Trimethoxy-2-(4-methoxyphenyl)-7-(phenylmethoxy)-4H-1-benzopyran-4-one
CAS No.:10176-76-8
Molecular Formula:C26H24O7
Molecular Weight:448.472
Hs Code.:
DSSTox Substance ID:DTXSID201140732
Mol file:10176-76-8.mol

Synonyms:DTXSID201140732;5,6,8-Trimethoxy-2-(4-methoxyphenyl)-7-(phenylmethoxy)-4H-1-benzopyran-4-one;10176-76-8

Suppliers and Price of 5,6,8-Trimethoxy-2-(4-methoxyphenyl)-7-(phenylmethoxy)-4H-1-benzopyran-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5,6,8-Trimethoxy-2-(4-methoxyphenyl)-7-(phenylmethoxy)-4H-1-benzopyran-4-one

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:448.15220310
Heavy Atom Count:33
Complexity:666

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OCC4=CC=CC=C4)OC

Technology Process of 5,6,8-Trimethoxy-2-(4-methoxyphenyl)-7-(phenylmethoxy)-4H-1-benzopyran-4-one

There total 13 articles about 5,6,8-Trimethoxy-2-(4-methoxyphenyl)-7-(phenylmethoxy)-4H-1-benzopyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 100-44-7
benzyl chloride

: 73213-66-8
7-hydroxy-5,6,8,4′-tetramethoxyflavone

: 10176-76-8
7-Benzyloxy-5,6,8-trimethoxy-2-(4-methoxy-phenyl)-chromen-4-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 0.0833333h;
DOI:10.1246/bcsj.69.1033

Reference yield:

: 56002-82-5
2,3-diacetoxy-1,4,5-trimethoxy-benzene

: 10176-76-8
7-Benzyloxy-5,6,8-trimethoxy-2-(4-methoxy-phenyl)-chromen-4-one

Guidance literature:: Multi-step reaction with 12 steps

1: 77 percent / K₂CO₃ / acetone; dimethylformamide / 50 h / Heating

2: 10percent aq. NaOH / methanol / 0.5 h / Ambient temperature

3: K₂CO₃ / acetone / 3 h / Heating

4: H₂ / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature

5: pyridine

6: 1.) AcOH, BF₃(g), 2.) pyridine / 1.) from 50 to 60 deg C, 5 h

7: 10percent aq. NaOH / methanol / 0.25 h / Ambient temperature

8: (i-Pr)2NEt / CH₂Cl₂ / 0.83 h / 5 °C

9: pyridine / 3 h / 60 - 70 °C

10: KOH, pyridine / 2 h / 60 °C

11: conc. H₂SO₄, HOAc / 1 h / 50 °C

12: 98 percent / K₂CO₃ / dimethylformamide / 0.08 h / 150 °C

With pyridine; potassium hydroxide; sodium hydroxide; sulfuric acid; boron trifluoride; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1246/bcsj.69.1033

Reference yield:

: 7507-98-4
1-(2-hydroxy-3,4,6-trimethoxyphenyl)ethanone

: 10176-76-8
7-Benzyloxy-5,6,8-trimethoxy-2-(4-methoxy-phenyl)-chromen-4-one

Guidance literature:: Multi-step reaction with 14 steps

1: 4percent aq. NaOH, 6percent aq. H₂O₂ / methanol / 2 h / 50 °C

2: pyridine

3: 77 percent / K₂CO₃ / acetone; dimethylformamide / 50 h / Heating

4: 10percent aq. NaOH / methanol / 0.5 h / Ambient temperature

5: K₂CO₃ / acetone / 3 h / Heating

6: H₂ / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature

7: pyridine

8: 1.) AcOH, BF₃(g), 2.) pyridine / 1.) from 50 to 60 deg C, 5 h

9: 10percent aq. NaOH / methanol / 0.25 h / Ambient temperature

10: (i-Pr)2NEt / CH₂Cl₂ / 0.83 h / 5 °C

11: pyridine / 3 h / 60 - 70 °C

12: KOH, pyridine / 2 h / 60 °C

13: conc. H₂SO₄, HOAc / 1 h / 50 °C

14: 98 percent / K₂CO₃ / dimethylformamide / 0.08 h / 150 °C

With pyridine; potassium hydroxide; sodium hydroxide; sulfuric acid; boron trifluoride; hydrogen; dihydrogen peroxide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1246/bcsj.69.1033