2-Hydroxy-5-phenylnicotinic acid

Base Information

• Chemical Name: 2-Hydroxy-5-phenylnicotinic acid
• CAS No.: 10177-08-9
• Molecular Formula: C12H9NO3
• Molecular Weight: 215.208
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00438920
• Nikkaji Number: J666.774K
• Wikidata: Q82254769
• Mol file: 10177-08-9.mol

Synonyms:10177-08-9;2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid;2-HYDROXY-5-PHENYLNICOTINIC ACID;2-oxo-5-phenyl-1H-pyridine-3-carboxylic Acid;SCHEMBL396923;2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylicacid;SCHEMBL11817492;DTXSID00438920;SIHMMTANWQXEHE-UHFFFAOYSA-N;MFCD00835053;AKOS015892177;AKOS015999358;DS-17500;CS-0156456;2-Hydroxy-5-phenyl-3-pyridinecarboxylic acid;C71085;A897084;1,2-Dihydro-2-oxo-5-phenyl-3-pyridinecarboxylic acid;1,2-Dihydro-5-phenyl-2-oxopyridine-3-carboxylic acid;2-Oxo-5-phenyl-1,2-dihydro-pyridine-3-carboxylic acid

Chemical Property of 2-Hydroxy-5-phenylnicotinic acid

Chemical Property:

• PSA: 70.42000
• LogP: 2.15240
• Storage Temp.: 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 215.058243149
• Heavy Atom Count: 16
• Complexity: 376

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Hydroxy-5-phenylnicotinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CNC(=O)C(=C2)C(=O)O

Technology Process of 2-Hydroxy-5-phenylnicotinic acid

There total 5 articles about 2-Hydroxy-5-phenylnicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

methyl 1,2-dihydro-2-oxo-5-phenyl-3-pyridinecarboxylate → 1,2-dihydro-2-oxo-5-phenyl-3-pyridinecarboxylic acid (10177-08-9)

Guidance literature:

With hydrogenchloride; acetic acid; for 18h; Heating;

DOI:10.1021/jo00117a029

Reference yield:

1,2-dihydro-2-oxo-5-phenyl-3-pyridinecarbonitrile (35982-93-5) → 1,2-dihydro-2-oxo-5-phenyl-3-pyridinecarboxylic acid (10177-08-9)

Guidance literature:

In sodium hydroxide; sulfuric acid;

Reference yield:

1,2-dihydro-5-phenyl-2(1H)-oxo-3-pyridinecarboxamide + malonodiamide (108-13-4) → 1,2-dihydro-2-oxo-5-phenyl-3-pyridinecarboxylic acid (10177-08-9)

Guidance literature:

With sulfuric acid;

upstream raw materials:

malonodiamide

1,2-dihydro-2-oxo-5-phenyl-3-pyridinecarbonitrile

Downstream raw materials:

2-chloro-5-phenyl-3-pyridinecarboxylic acid

2-[2-(dimethylamino)ethyl]-2,3-dihydro-4-methyl-7-phenylpyrido-[3,2-f]-1,4-oxazepine-5(4H)-thione

2-<(1-methyl-3-pyrrolidinyl)oxy>-5-phenyl-3-pyridinecarboxylic acid sodium salt

2-(2-chloroethyl)-3,4-dihydro-4-methyl-7-phenylpyrido<3,2-f>-1,4-oxazepine-5(2H)-thione

Refernces

• 1、 -. "Substituted 6-phenyl-5,6,7,8-tetrahydro-1,2,4-triazolo-[4,3-a]pyridines". . . Retrieved 2008/06/13.
• 2、 -. "Substituted 6-phenyl-1,2,4-triazolo[4,3-a]pyridines". . . Retrieved 2008/06/13.