Z-LeuΨGly-Sta-Leu-NHCH2Ph

Base Information

Chemical Name:Z-LeuΨGly-Sta-Leu-NHCH2Ph
CAS No.:118405-05-3
Molecular Formula:C₃₈H₅₈N₄O₇
Molecular Weight:682.901
Hs Code.:

Synonyms:

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Chemical Property of Z-LeuΨGly-Sta-Leu-NHCH2Ph

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Technology Process of Z-LeuΨGly-Sta-Leu-NHCH2Ph

There total 5 articles about Z-LeuΨGly-Sta-Leu-NHCH2Ph which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2018-66-8
Z-Leu-OH

: 118405-05-3,124339-03-3,124339-33-9
Z-LeuΨGly-Sta-Leu-NHCH2Ph

Guidance literature:: Multi-step reaction with 8 steps

1: 1-methylpiperidine / ethyl acetate / 0.17 h / -20 °C

2: ethyl acetate; diethyl ether / 2 °C

3: HBr gas / diethyl ether / -20 °C

4: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) a) 0 deg C, 0.5 h, b) room temp., 1 h

5: H₂ / 20percent Pd/C / methanol / 3 h

6: toluene / 2 h / Heating

7: HOBT/DCC, Et₃N / dimethylformamide / Ambient temperature

8: NaBH₄ / ethanol / 2 h / from 0 deg C to room temp.

With N-methylcyclohexylamine; sodium tetrahydroborate; hydrogen bromide; hydrogen; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00164a058

Reference yield:

: 102123-80-8
C₁₉H₂₇NO₆

: 118405-05-3,124339-03-3,124339-33-9
Z-LeuΨGly-Sta-Leu-NHCH2Ph

Guidance literature:: Multi-step reaction with 7 steps

1: ethyl acetate; diethyl ether / 2 °C

2: HBr gas / diethyl ether / -20 °C

3: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) a) 0 deg C, 0.5 h, b) room temp., 1 h

4: H₂ / 20percent Pd/C / methanol / 3 h

5: toluene / 2 h / Heating

6: HOBT/DCC, Et₃N / dimethylformamide / Ambient temperature

7: NaBH₄ / ethanol / 2 h / from 0 deg C to room temp.

With sodium tetrahydroborate; hydrogen bromide; hydrogen; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00164a058