C₂₁H₂₀ClF₄N₅O₂

Base Information

Chemical Name:C₂₁H₂₀ClF₄N₅O₂
CAS No.:1613395-76-8
Molecular Formula:C₂₁H₂₀ClF₄N₅O₂
Molecular Weight:485.869
Hs Code.:

C<sub>21</sub>H<sub>20</sub>ClF<sub>4</sub>N<sub>5</sub>O<sub>2</sub>

Synonyms:

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Chemical Property of C₂₁H₂₀ClF₄N₅O₂

Chemical Property:

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Technology Process of C₂₁H₂₀ClF₄N₅O₂

There total 5 articles about C₂₁H₂₀ClF₄N₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138907-70-7
ethyl 5-amino-1-(3-fluorophenyl)-1H-pyrazole-4-carboxylate

: 1613395-76-8
C₂₁H₂₀ClF₄N₅O₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: diiodomethane; isopentyl nitrite / acetonitrile / 1 h / 20 - 50 °C

2.1: lithium hydroxide monohydrate; water / methanol; tetrahydrofuran

3.1: triethylamine; diphenyl phosphoryl azide / 20 - 60 °C / Molecular sieve

4.1: palladium diacetate; tricyclohexylphosphine; potassium phosphate / toluene; water / 7 h / 100 - 110 °C / Inert atmosphere

4.2: 100 °C

5.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

6.1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 4 h / 20 °C

With hydrogenchloride; potassium phosphate; lithium hydroxide monohydrate; diiodomethane; diphenyl phosphoryl azide; water; trimethylaluminum; palladium diacetate; triethylamine; tricyclohexylphosphine; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1,2-dichloro-ethane; toluene; acetonitrile; 4.1: |Suzuki Coupling;

Reference yield:

: 1613395-67-7
ethyl 5-iodo-1-(3-fluorophenyl)-1H-pyrazole-4-carboxylate

: 1613395-76-8
C₂₁H₂₀ClF₄N₅O₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hydroxide monohydrate; water / methanol; tetrahydrofuran

2.1: triethylamine; diphenyl phosphoryl azide / 20 - 60 °C / Molecular sieve

3.1: palladium diacetate; tricyclohexylphosphine; potassium phosphate / toluene; water / 7 h / 100 - 110 °C / Inert atmosphere

3.2: 100 °C

4.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

5.1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 4 h / 20 °C

With hydrogenchloride; potassium phosphate; lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; trimethylaluminum; palladium diacetate; triethylamine; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1,2-dichloro-ethane; toluene; 3.1: |Suzuki Coupling;

Reference yield:

: 1567126-75-3
5-iodo-1-(3-fluorophenyl)-1H-pyrazole-4-carboxylic acid

: 1613395-76-8
C₂₁H₂₀ClF₄N₅O₂

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; diphenyl phosphoryl azide / 20 - 60 °C / Molecular sieve

2.1: palladium diacetate; tricyclohexylphosphine; potassium phosphate / toluene; water / 7 h / 100 - 110 °C / Inert atmosphere

2.2: 100 °C

3.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

4.1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 4 h / 20 °C

With hydrogenchloride; potassium phosphate; diphenyl phosphoryl azide; trimethylaluminum; palladium diacetate; triethylamine; tricyclohexylphosphine; In 1,4-dioxane; water; 1,2-dichloro-ethane; toluene; 2.1: |Suzuki Coupling;