digoxigenin

Base Information

• Chemical Name: digoxigenin
• CAS No.: 105820-99-3
• Molecular Formula: C₂₅H₃₆O₆
• Molecular Weight: 432.557
• Mol file: 105820-99-3.mol

Synonyms:

Chemical Property of digoxigenin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of digoxigenin

There total 1 articles about digoxigenin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + digoxigenin (1672-46-4) → 12β-acetoxy-3β,14β-dihydroxy-5β,14β-card-20(22)-enolide (20830-74-4,36083-89-3,91024-45-2,105820-99-3) + 3,12-Diacetyl-digoxingenin (6078-59-7)

Guidance literature:

With pyridine;

DOI:10.1002/hlca.19560390629

Reference yield: 99.0%

12β-acetoxy-3β,14β-dihydroxy-5β,14β-card-20(22)-enolide (20830-74-4,36083-89-3,91024-45-2,105820-99-3) + tert-butylchlorodiphenylsilane (58479-61-1) → 3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-card-20(22)-enolide (1393730-33-0)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1039/c2cc34404a

Reference yield: 88.0%

3,4,6-tri-O-benzyl-D-galactal (80040-79-5) + 12β-acetoxy-3β,14β-dihydroxy-5β,14β-card-20(22)-enolide (20830-74-4,36083-89-3,91024-45-2,105820-99-3) → 3-O-(2-deoxy-3,4,6-tri-O-benzyl-α-D-galactopyranosyl)-12-O-acetyl-digoxigenin

Guidance literature:

With bromopropionitrile; tetrabutylammonium trifluoromethylsulfonate; In dichloromethane; at 20 ℃; Electrochemical reaction;

DOI:10.1002/anie.202006115

upstream raw materials:

acetic anhydride

digoxigenin

Downstream raw materials:

P57AS3

3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-pregn-20-one

3β-(tert-butyldiphenylsiloxy)-20,20-ethylenedioxy-14β-hydroxy-5β-pregn-12β-acetate

14β-hydroxypregn-5-ene-12β-tigloyl-20-one-3-O-(β-D-thevetopyranosyl)-(1->4)-α-D-cymaropyranosyl-(1->4)-β-D-cymaropyranoside