(3-ethynyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid 3-(tert-butyl-diphenyl-silanyloxy)-2-[2-(3-ethynyl-quinolin-6-yloxy)-2-methylsulfanyl-acetylamino]-2-methyl-propyl ester

Base Information

• Chemical Name: (3-ethynyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid 3-(tert-butyl-diphenyl-silanyloxy)-2-[2-(3-ethynyl-quinolin-6-yloxy)-2-methylsulfanyl-acetylamino]-2-methyl-propyl ester
• CAS No.: 1128039-53-1
• Molecular Formula: C₄₈H₄₇N₃O₆S₂Si
• Molecular Weight: 854.135
• Mol file: 1128039-53-1.mol

Synonyms:

Chemical Property of (3-ethynyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid 3-(tert-butyl-diphenyl-silanyloxy)-2-[2-(3-ethynyl-quinolin-6-yloxy)-2-methylsulfanyl-acetylamino]-2-methyl-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-ethynyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid 3-(tert-butyl-diphenyl-silanyloxy)-2-[2-(3-ethynyl-quinolin-6-yloxy)-2-methylsulfanyl-acetylamino]-2-methyl-propyl ester

There total 1 articles about (3-ethynyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid 3-(tert-butyl-diphenyl-silanyloxy)-2-[2-(3-ethynyl-quinolin-6-yloxy)-2-methylsulfanyl-acetylamino]-2-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(3-ethynyl-6-quinolyl)oxy]-2-methylsulfanyl-acetic acid (1128039-27-9) + 2-amino-3-[tert-butyl(diphenyl)silyl]oxy-2-methylpropan-1-ol (280753-14-2) → rac-(R,R)-N-[1-(tert-butyl-diphenyl-silanyloxymethyl)-2-hydroxy-1-methyl-ethyl]-2-(3-ethynyl-quinolin-6-yloxy)-2-methylsulfanyl-acetamide + rac-(R,S)-N-[1-(tert-butyl-diphenyl-silanyloxymethyl)-2-hydroxy-1-methyl-ethyl]-2-(3-ethynyl-quinolin-6-yloxy)-2-methylsulfanyl-acetamide + (3-ethynyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid 3-(tert-butyl-diphenyl-silanyloxy)-2-[2-(3-ethynyl-quinolin-6-yloxy)-2-methylsulfanyl-acetylamino]-2-methyl-propyl ester (1128039-53-1)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In acetonitrile; at 20 ℃; for 16h; Product distribution / selectivity;

Reference yield:

(3-ethynyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid 3-(tert-butyl-diphenyl-silanyloxy)-2-[2-(3-ethynyl-quinolin-6-yloxy)-2-methylsulfanyl-acetylamino]-2-methyl-propyl ester (1128039-53-1) → rac-(R,R)-N-[1-(tert-butyl-diphenyl-silanyloxymethyl)-2-hydroxy-1-methyl-ethyl]-2-(3-ethynyl-quinolin-6-yloxy)-2-methylsulfanyl-acetamide + rac-(R,S)-N-[1-(tert-butyl-diphenyl-silanyloxymethyl)-2-hydroxy-1-methyl-ethyl]-2-(3-ethynyl-quinolin-6-yloxy)-2-methylsulfanyl-acetamide

Guidance literature:

With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 1.33333h; pH=11; Product distribution / selectivity;

upstream raw materials:

2-[(3-ethynyl-6-quinolyl)oxy]-2-methylsulfanyl-acetic acid

2-amino-3-[tert-butyl(diphenyl)silyl]oxy-2-methylpropan-1-ol