2-Amino-3-((tert-butyldiphenylsilyl)oxy)-2-methylpropan-1-ol

Base Information

• Chemical Name: 2-Amino-3-((tert-butyldiphenylsilyl)oxy)-2-methylpropan-1-ol
• CAS No.: 280753-14-2
• Molecular Formula: C₂₀H₂₉NO₂Si
• Molecular Weight: 343.541
• Mol file: 280753-14-2.mol

Synonyms:2-amino-3-[tert-butyl(diphenyl)silyl]oxy-2-methylpropan-1-ol

Chemical Property of 2-Amino-3-((tert-butyldiphenylsilyl)oxy)-2-methylpropan-1-ol

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-3-((tert-butyldiphenylsilyl)oxy)-2-methylpropan-1-ol 95+% ^*data from reagent suppliers

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Technology Process of 2-Amino-3-((tert-butyldiphenylsilyl)oxy)-2-methylpropan-1-ol

There total 2 articles about 2-Amino-3-((tert-butyldiphenylsilyl)oxy)-2-methylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-Amino-2-methylpropane-1,3-diol (115-69-5) + tert-butylchlorodiphenylsilane (58479-61-1) → 2-amino-3-[tert-butyl(diphenyl)silyl]oxy-2-methylpropan-1-ol (280753-14-2) + 2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-ethylamine

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1016/S0040-4039(00)00626-2

Reference yield:

2-Amino-2-methylpropane-1,3-diol (115-69-5) + tert-butylchlorodiphenylsilane (58479-61-1) → 2-amino-3-[tert-butyl(diphenyl)silyl]oxy-2-methylpropan-1-ol (280753-14-2)

Guidance literature:

2-Amino-2-methylpropane-1,3-diol; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.916667h;

tert-butylchlorodiphenylsilane; In tetrahydrofuran; at 0 - 20 ℃; for 17h;

Reference yield: 68.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-amino-3-[tert-butyl(diphenyl)silyl]oxy-2-methylpropan-1-ol (280753-14-2) → tert-butyl 4-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-methyl-2-oxooxazolidine-3-carboxylate

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tetlet.2020.152463

upstream raw materials:

2-Amino-2-methylpropane-1,3-diol

tert-butylchlorodiphenylsilane

Downstream raw materials:

(3-ethynyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid 3-(tert-butyl-diphenyl-silanyloxy)-2-[2-(3-ethynyl-quinolin-6-yloxy)-2-methylsulfanyl-acetylamino]-2-methyl-propyl ester

N-[1-(tert-butyl-diphenyl-silanyloxymethyl)-2-hydroxy-1-methyl-ethyl]-2-(3-ethynyl-quinolin-6-yloxy)-2-methylsulfanyl-acetamide

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