3-fluoro-2-methyl-α-isonitrosoacetanilide

Base Information

• Chemical Name: 3-fluoro-2-methyl-α-isonitrosoacetanilide
• CAS No.: 114895-95-3
• Molecular Formula: C₉H₉FN₂O₂
• Molecular Weight: 196.181
• Mol file: 114895-95-3.mol

Synonyms:

Chemical Property of 3-fluoro-2-methyl-α-isonitrosoacetanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-fluoro-2-methyl-α-isonitrosoacetanilide

There total 1 articles about 3-fluoro-2-methyl-α-isonitrosoacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloral hydrate (302-17-0) + 3-fluoro-2-methylaniline (443-86-7) → 3-fluoro-2-methyl-α-isonitrosoacetanilide (114895-95-3)

Guidance literature:

With hydrogenchloride; hydroxylamine sulfate; sodium sulfate; In water;

DOI:10.1021/jm00105a034

Reference yield:

3-fluoro-2-methyl-α-isonitrosoacetanilide (114895-95-3) → 2-amino-4-fluoro-3-methylbenzoic acid (129833-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₃SO₃H / 70 - 80 °C

2: KOH, KCl, 27percent H₂O₂ / 20 °C

With potassium hydroxide; methanesulfonic acid; potassium chloride; dihydrogen peroxide;

DOI:10.1021/jm00105a034

Reference yield:

3-fluoro-2-methyl-α-isonitrosoacetanilide (114895-95-3) → 4-fluoro-2-iodo-3-methylbenzoic acid (129833-35-8)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₃SO₃H / 70 - 80 °C

2: KOH, KCl, 27percent H₂O₂ / 20 °C

3: 1.) concd. H₂SO₄, NaNO₂, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C

With potassium hydroxide; methanesulfonic acid; sulfuric acid; potassium chloride; dihydrogen peroxide; potassium iodide; sodium nitrite;

DOI:10.1021/jm00105a034

upstream raw materials:

chloral hydrate

3-fluoro-2-methylaniline

Downstream raw materials:

6-fluoro-7-methylindoline-2,3-dione

2-amino-4-fluoro-3-methylbenzoic acid

4-fluoro-2-iodo-3-methylbenzoic acid

Refernces