(1R,2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-1-(2-methyl-propane-2-sulfonyl)-2-trimethylsilanylethynyl-cyclohexane

Base Information

• Chemical Name: (1R,2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-1-(2-methyl-propane-2-sulfonyl)-2-trimethylsilanylethynyl-cyclohexane
• CAS No.: 84849-38-7
• Molecular Formula: C₂₂H₄₄O₃SSi₂
• Molecular Weight: 444.827
• Mol file: 84849-38-7.mol

Synonyms:

Chemical Property of (1R,2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-1-(2-methyl-propane-2-sulfonyl)-2-trimethylsilanylethynyl-cyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-1-(2-methyl-propane-2-sulfonyl)-2-trimethylsilanylethynyl-cyclohexane

There total 1 articles about (1R,2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-1-(2-methyl-propane-2-sulfonyl)-2-trimethylsilanylethynyl-cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C5H9KSi + 3-(tert-butyldimethylsiloxy)-1-cyclohexenyl tert-butyl sulfone (75534-22-4) + methyl iodide (74-88-4) → (1R,2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-1-(2-methyl-propane-2-sulfonyl)-2-trimethylsilanylethynyl-cyclohexane + (1R,2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-1-(2-methyl-propane-2-sulfonyl)-2-trimethylsilanylethynyl-cyclohexane (84849-38-7,84893-98-1)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1) THF, -78 to 0 deg C, 0.5 h, 2) -78 to 25 deg C;

DOI:10.1021/jo00154a044

Reference yield: 71.0%

(1R,2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-1-(2-methyl-propane-2-sulfonyl)-2-trimethylsilanylethynyl-cyclohexane (84849-38-7,84893-98-1) → 3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-2-trimethylsilanylethynyl-cyclohexene (84863-62-7)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 1.5h;

DOI:10.1021/jo00154a044

Reference yield:

(1R,2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-1-(2-methyl-propane-2-sulfonyl)-2-trimethylsilanylethynyl-cyclohexane (84849-38-7,84893-98-1) → (1R,2S,3R)-3-Methyl-3-(2-methyl-propane-2-sulfonyl)-2-trimethylsilanylethynyl-cyclohexanol

Guidance literature:

With water; acetic acid; In tetrahydrofuran; at 65 ℃; for 10h;

DOI:10.1021/jo00154a044

upstream raw materials:

3-(tert-butyldimethylsiloxy)-1-cyclohexenyl tert-butyl sulfone

methyl iodide

Downstream raw materials:

3-Methyl-2-trimethylsilanylethynyl-cyclohex-2-enone

3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-2-trimethylsilanylethynyl-cyclohexene