C₁₈H₂₄O₂

Base Information

• Chemical Name: C₁₈H₂₄O₂
• CAS No.: 133663-83-9
• Molecular Formula: C₁₈H₂₄O₂
• Molecular Weight: 272.387
• Mol file: 133663-83-9.mol

Synonyms:

Chemical Property of C₁₈H₂₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₄O₂

There total 17 articles about C₁₈H₂₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

benzyl bromide (100-39-0) + C11H18O2 (85757-79-5) → C18H24O2 (133663-83-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.3230

Reference yield:

methyl (S)-3-oxo-4-(2-cyclopentenyl)butyrate (133663-79-3) → C18H24O2 (133663-83-9)

Guidance literature:

Multi-step reaction with 10 steps

1: p-toluenesulfonyl azide, NEt₃ / acetonitrile / 12 h / 20 °C

2: copper(II) acetylacetonate / toluene / 2 h / Heating

3: 78 percent / conc. H₂SO₄, HOAc / 2 h / 20 °C

4: conc. H₂SO₄, HOAc / 0.5 h / Heating

5: K₂CO₃ / methanol / 2 h / 20 °C

6: diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 14 h / Ambient temperature

7: K₂CO₃ / methanol / 2 h / 20 °C

8: 1.) lithium diethylamide / 1.) THF, toluene, 0 deg C, 10 min, 2.) 0.5 h

9: 1 percent / Zn-Cu, I₂ / diethyl ether / 1 h / Heating

10: 50 percent / NaH / dimethylformamide

With 4-toluenesulfonyl azide; sulfuric acid; lithium diethylamide; iodine; copper; sodium hydride; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; zinc; diethylazodicarboxylate; copper acetylacetonate; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1248/cpb.38.3230

Reference yield:

(1R,5R,6S)-6-benzyloxy-cis-bicyclo<3.3.0>octan-3-one (85757-74-0) → C18H24O2 (133663-83-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / H₂ / 5percent Pd-C / methanol / 16 h / Ambient temperature

2: 1.) lithium diethylamide / 1.) THF, toluene, 0 deg C, 10 min, 2.) 0.5 h

3: 1 percent / Zn-Cu, I₂ / diethyl ether / 1 h / Heating

4: 50 percent / NaH / dimethylformamide

With lithium diethylamide; hydrogen; iodine; copper; sodium hydride; zinc; palladium on activated charcoal; In methanol; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.3230

upstream raw materials:

benzyl bromide

C₁₁H₁₈O₂

(1R,2S,5S)-2-hydroxy-7-methoxymethylene-cis-bicyclo<3.3.0>octane

methyl (S)-3-oxo-4-(2-cyclopentenyl)butyrate

Downstream raw materials:

(2R,3aR,4S,6aS)-4-Benzyloxy-2-methyl-octahydro-pentalene-2-carbaldehyde