Pyrimidine, 4,6-dichloro-5-phenyl-2-(2-pyridinyl)-

Base Information

Chemical Name:Pyrimidine, 4,6-dichloro-5-phenyl-2-(2-pyridinyl)-
CAS No.:10198-78-4
Molecular Formula:C₁₅H₉Cl₂N₃
Molecular Weight:302.163
Hs Code.:
DSSTox Substance ID:DTXSID50476630
Mol file:10198-78-4.mol

Synonyms:10198-78-4;Pyrimidine, 4,6-dichloro-5-phenyl-2-(2-pyridinyl)-;DTXSID50476630;AKOS014767578;4,6-dichloro-5-phenyl-2-(2-pyridyl)pyrimidine

Suppliers and Price of Pyrimidine, 4,6-dichloro-5-phenyl-2-(2-pyridinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrimidine, 4,6-dichloro-5-phenyl-2-(2-pyridinyl)-

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:301.0173527
Heavy Atom Count:20
Complexity:298

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(N=C(N=C2Cl)C3=CC=CC=N3)Cl

Technology Process of Pyrimidine, 4,6-dichloro-5-phenyl-2-(2-pyridinyl)-

There total 1 articles about Pyrimidine, 4,6-dichloro-5-phenyl-2-(2-pyridinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10198-78-4
4,6-dichloro-5-phenyl-2-(2-pyridyl)pyrimidine

Guidance literature:: 4,6-Dihydroxy-5-phenyl-2-pyridyl-2-pyrimidin, POCl3;
DOI:10.1021/jo01280a064

Reference yield: 89.0%

: 17084-13-8
potassium hexafluorophosphate

: 32648-33-2
trans-bis((diphenylthio)ethane)dichlororuthenium(II)

: 10198-78-4
4,6-dichloro-5-phenyl-2-(2-pyridyl)pyrimidine

: [Ru(II)((diphenylthio)ethane)(4,6-dichloro-5-phenyl-2-(2-pyridyl)pyrimidine)](PF₆)2

Guidance literature:: In not given; Ru complex with four molar excess of (C5NH4)(C4N2)Cl2(C6H5) refluxed (2-3 h); solvent removed in vac.; solid treated with aq. soln. of KPF6; recrystd. from acetone/Et2O; solid collected; washed with hexane; elem. anal.;
DOI:10.1023/A:1021158931775

Reference yield: 74.0%

: 26042-63-7
silver(I) hexafluorophosphate

: bis(2,2'-bipyridine)dichlororuthenium(II) dihydrate

: 10198-78-4
4,6-dichloro-5-phenyl-2-(2-pyridyl)pyrimidine

: 259260-67-8
Ru(C₁₀H₈N₂)2(C₆H₅C₉H₄ClN₃O)⁽¹⁺⁾*PF₆^(1-)=[Ru(C₁₀H₈N₂)2(C₆H₅C₉H₄ClN₃O)]PF₆

Guidance literature:: In acetone; byproducts: AgCl; refluxing Ru-complex with excess of AgPF6 for 2 h, filtration off of AgCl, addn. of 2 equiv. of ligand, refluxing for 3 h; cooling to room temp., filtration, concn. (reduced pressure), chromy. (Al2O3, CHCl3/Me2CO=3:1), concn., pptn. on Et2O addn., filtration, drying (vac., room temp.); elem. anal.;
DOI:10.1016/S0020-1693(99)00321-7